5 口腔癌におけるp53の発現および Ki-67抗原の局在と腫瘍の分化度および浸潤性との関連 (第433回大阪歯科学会例会)

概要

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We investigated the expression of p53 and the localization of Ki-67-positive cells in oral squamous cell carcinomas (SCCs), and the correlation between these factors and tumor differentiation and invasion. p53 showed expression in 28 of 30 cases, the degree being higher in moderate and poorly differentiated than in well differentiated carcinoma. The average of observation of Ki-67-positive cells in well, moderate and poorly differentiated carcinomas was 27.2, 31.7 and 36.5%, respectively. In contrast, the corresponding rates were 23.2% in grade 2, 28.3% in grade 3, 30.5% in grade 4C and 38.7% in grade 4D, according to the classification of Yamamoto et al. These results indicate that p53 is responsible for carcinogenesis in oral SCC, and that tumor proliferative activity is higher in poorly differentiated and grade 4 carcinomas.
大阪歯科学会の論文
1994-02-25