<総説(学内研究紹介)>ウイルスの宿主自然免疫系からの回避戦略

概要

論文の詳細を見る
In order to establish infection to host cells, viruses suppress or escape from the host immune response against microorganisms by various strategies. Interferon (IFN) system is an important contributor of innate immunity. IFN is induced by viral infection, and it promotes antiviral state through induction and/or activation of the effector molecules. Many viruses possess the suppression mechanisms for the anti-viral effector molecules, whereas they also perform inhibition of IFN signaling pathway, JAK/STAT pathway. We consider that latter is a most effective strategy counteracting IFN function, because the signaling pathway is an entrance of the system. The strategies counteracting JAK/STAT pathway are varied among virus species. Viruses perform (i) degradation of JAK/STAT components, (ii) suppression of activation (phosphorylation) of the components, (iii) inhibition of nuclear translocation of activated transcription factor, and (iv) induction of host JAK/STAT negative regulator. In this review, we describe details of these strategies, especially our recent results of HSV-1, measles virus and mumps virus.
札幌医科大学の論文
2005-08-01