速効性を期待したニフェジピン投与方法の検討 : 高血圧患者を対象とした臨床試験より

概要

論文の詳細を見る
The nifedipine capsule is frequently administered by the sublingual route to provide a rapid effect, especially in patients who require an immediate reduction of an elevated blood pressure. However, many problems have also been reported in association with dispensing nifedipine capsules for the rapid management of systemic hypertension. In this study, 2 procedures of nifedipine administration for immediate treatment were evaluated regarding the efficacy and usefulness In a clinical setting. Nifedipine liquid (10 mg) was withdrawn from a capsule with a 1.0-mL syringe through an 18-gauge needle and then was administered sublingually to 7 patients. nifedipine granules (10 mg) were administrated orally with a glass of water to 6 patients. The oral administration of fine granules provided higher serum levels of nifedipine with a more rapid onset than the sublingual administration of liquid in the first 30 min. In addition, the former administration technique also provided prompt and significant reduction of the systolic blood pressure, especially in patients with > 170 mmHg systolic blood pressure. In conclusion, among the commercially available nifedipine products, nifedipine fine granules were found to be both easy to use and effective for immediate management of systemic hypertension with a rapid onset of action.
日本医療薬学会の論文
1999-06-10