内科領域における子宮摘出後更年期デプレッション患者のゴナドトロピン分泌動態

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The aim of the present investigation was to study plasma gonadotropin secretion after infusion of LH-RH. The subjects were postmenopausal depressed women after hysterectomy seen in internal medical clinics. Psychological tests and an autonomic function test using microvibration were carried out. It was suggested that hysterectomy in climacterium was important as a risk to cause depression. We therefore made literature surveys of hysterectomy and depression. It was found through endocrinological data that plasma LH concentration in primary depression was less than that in the contrl and in secondary depression. However, plasma FSH concentration showed no significant differences between 3 groups (control, primary depression and secondary depression). Plasma LH concentration in LH-RH test revealed high responses in the order of primary depression, control and secondary depression. However, plasma FSH showed no significant differences between 3 groups. The mean of LH concentration after LH-RH in 5 primary depression revealed hypo-poor response, and the mean of LH in secondary depression revealed hyper-well response.When comparisons were made between the anxiety type and the retarded type in clinical features of depression, gonadotropin response in LH-RH revealed no significant differences between primary depression and secondary depression. All patients with the retarded type of depression were classified under primary depression.Comparisons among psychological tests revealed that V items and M-R items of CMI and MAS scores had no significant difference. However, SRQ-D in primary depression increased significantly than in secondary depression. Plasma gonadotropin secretion was little affected by hysterectomy. The change of LH and FSH secretion might be influenced by affective disorders.
日本心身医学会の論文
1981-04-01

内科領域における子宮摘出後更年期デプレッション患者のゴナドトロピン分泌動態

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