ラット血清および肝臓脂質濃度に及ぼす卵黄リン脂質添加レベルの影響(自然科学編)

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The relationships between the dose of the yolk phospholipid and the lipid content of serum and liver were studied. Four weeks male SD rat was used. Because 7.5% addition of soybean phospholipid in diet had no problem, I used addition of 0%, 1%, 3%, 5% and 7% of egg-yolk phospholipid (PL) and add the olive oil adjust to 10% lipids content in the diet based on the AIN-93 composition. Rats were fed for 28 days. Serum total cholesterol, serum triglyceride and serum phospholipid were elevated significantly in the PL1% and 3% experimental group, but in the PL5% and PL7% experimental groups, the serum lipids levels returned to the same level of control group. Although significant difference was not detected, the liver cholesterol was in a lower tendency in the PL5% and PL7% experimental groups. Liver triglyceride was decreased in all PL-added experimental groups compared with the control group. The amount of stearic acid in the feces increased in PL5% and PL7% experimental groups. These results indicate more than 5% of egg-yolk phospholipid decreased the cholesterol pool in the body and show the effect to control the serum cholesterol. Moreover, the total weight of the feces and the content of steraric acid increased in the PL7% experimental group. Therefore, it is presumed that the fatty acid absorption in the small intestine was inhibited and excreted in the feces.
千葉県立衛生短期大学の論文