<原著>造血器疾患に合併した重症感染症における各種抗生物質の治療効果と好中球数の影響

概要

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Seventy-six patients with hematopoietic disorders, mainly acute leukemia, with 214 times of severe infectious episodes were treated with high dose 15 kinds of antibiotic agents (cephems, 9; penicillins, 3; aminoglycosides, 2; other, 1). The response rate as a whole was 53.7% and that of each antibiotic agent ranged from 26.3 to 68.8%. The response rates of antibiotic agents in each infection were as follows, 33.3% in septicemia, 55.9% in septicemia suspected, 55.6% in respiratory tract infection, 66.7% in oral infection, 80% in anal abscess and 100% in urinary tract infection. There was no significant change in initial neutrophil count on response rate. The lowest response rate was observed in patients with persistent severe neutropenia (less than 100/μl). Patients who showed an increasing neutrophil count during therapy had a higher response rate than those in whom the neutrophil count decreased or remained unchanged. Gram-negative bacillary infections and Gram-positive infections had response rates of 54.3% and 26.8%, respectively. There was a slight difference (p<0.10) in therapeutic effects between the patients with (46.3%) and without (58.7%) any prior antibiotic treatment. The rate of adverse effects was 4.8% or less.
近畿大学の論文
1984-12-30