<症例>OK-432併用制癌剤動注療法により消失した胃癌肝転移の1例

概要

論文の詳細を見る
A 58-year-old male was diagnosed as having a gastric carcinoma with synchronous multiple liver metastases. He underwent total gastrectomy and received selective hepatic infusion chemotherapy (MMC and 5-FU) combined with OK-432. 5-FU was infused continuously at the dose of 250mg/day, while MMC and OK-432 were administered in one shot. The initial dose of OK-432 was 0.5 KE, and the dosage was increased gradually up to the maintenance dose of 5 KE. The infusion immunochemotherapy was continued for 62 days, so 15.5 gr of 5-FU, 32mg of MMC and 100.5 KE of OK-432 were administered for the total dose. Only one side effect in this case was fever immediately after infusion of OK-432. Diminution of multiple liver metastases and their disappearance was confirmed by abdominal CT scan 3 weeks and 3 months after infusion therapy, respectively. Eight months after the initial operation, increase of serum CEA level suggested the relapse of the liver metastases, but it was not found at relaparotomy except for the local recurrence located between the abdominal wall and the left lobe of the liver. The reccurent mass was resected radically, and the patient keeps in good health now. Thus, intra-arterial chemotherapy combined with OK-432 can be expected of its effectiveness for the treatment of liver metastasis.
近畿大学の論文
1988-03-25