Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression
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概要
- 論文の詳細を見る
Ethanol is a wildly abused substance that causes various problems and damage in our society. We examined the connection between the action of ethanol and the endocannabinoid system in corticostriatal synaptic transmission by recording excitatory post-synaptic currents (EPSCs). Acute treatment of ethanol (100 mM) inhibited corticostriatal EPSCs. In the presence of AM 251 (5 <I>μ</I>M), a cannabinoid 1 (CB<SUB>1</SUB>)-receptor antagonist, or AM 404 (5 <I>μ</I>M), a cannabinoid transporter inhibitor, the inhibition of corticostriatal EPSCs caused by ethanol was significantly reduced. This result suggests the possibility that the endocannabinoid system is involved in the action of ethanol. To support this result, brain slices were pre-treated with WIN 55,212-2 (1 <I>μ</I>M), a CB<SUB>1</SUB>-receptor agonist, following treatment of ethanol or treated with WIN 55,212-2 alone. There was no significant difference between each other, indicating that when CB<SUB>1</SUB> receptors are previously activated, the effect of ethanol is blunted. These results suggest that the activation of the endocannabinoid system is one of the possible mechanisms involved in ethanol-induced corticostriatal synaptic depression.
- 2012-09-20
著者
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Choi Se
Department Of Obstetrics And Gynecology College Of Medicine The Catholic University Of Korea
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Cho Hyeong
Department Of Pharmacology Medical Research Center College Of Medicine The Catholic University Of Ko
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Kim Ki
Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University
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JEUN Seung
Department of Pharmacology, Medical Research Center, College of Medicine, The Catholic University of
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Sung Ki-wug
Department Of Pharmacology Medical Research Center College Of Medicine The Catholic University Of Ko
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LI Qing-Zhong
Department of Pharmacology, College of Medicine, The Catholic University of Korea
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SUNG Ki-Wug
Department of Pharmacology, College of Medicine, The Catholic University of Korea
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KIM Ki
Department of Pharmacology, College of Medicine, The Catholic University of Korea
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JEUN Seung
Department of Pharmacology, College of Medicine, The Catholic University of Korea
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CHO Hyeong
Department of Pharmacology, College of Medicine, The Catholic University of Korea
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CHOI Se
Department of Pharmacology, College of Medicine, The Catholic University of Korea
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