Pregnancy-Associated Aortic Dilatation or Dissection in Japanese Women With Marfan Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
Background: Aortic dilatation and dissection are severe complications of pregnancy that may cause maternal death. The purpose of the present study was to investigate risk factors for aortic dilatation or dissection in pregnant Japanese women with Marfan syndrome. Methods and Results: A total of 28 patients with Marfan syndrome were investigated retrospectively during pregnancy and after delivery at 1 institution. These patients were divided into 2 groups: those who experienced aortic dilatation or dissection (group D, n=11) and those who did not (group ND, n=17). In group D, aortic dilatation or dissection occurred in 7 cases during pregnancy (2 in the 2nd trimester, 5 in the 3rd trimester) and 4 cases after birth. The 2 cases in the 2nd trimester involved aortic dilatation >60mm and those patients underwent hemiarch replacement and a David operation, respectively. Delivery by cesarean section (64% vs. 18%, P<0.05), sinus of Valsalva ≥40mm (86% vs. 21%, P<0.05), aortic size index (size of sinus of Valsalva/body surface area) ≥25mm/m2 (7/7, 100% vs. 0/14, 0%, P<0.0001), and faster growth of the sinus of the Valsalva (median, [interquartile range]: 0.41mm/month [0.23-0.66mm/month] vs. 0.05mm/month [-0.13 to 0.22mm/month]; P<0.05) were significantly higher in group D than in group ND. Conclusions: A large sinus of Valsalva, increased aortic size index, and rapid growth of the sinus of Valsalva are risk factors for aortic dilatation or dissection in pregnant Japanese women with Marfan syndrome. (Circ J 2011; 75: 2545-2551)
- 社団法人 日本循環器学会の論文
- 2011-10-25
著者
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Kamiya Chizuko
Department Of Perinatology National Cardiovascular Center
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Kamiya Chizuko
Department Of Medicine National Cardiovascular Center
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Kamiya Chizuko
Cardiovascular Division Of Internal Medicine National Cardiovascular Center
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Niwa Koichiro
Department Of Adult Chd Chiba Cardiovascular Center
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Niwa Koichiro
Department Of Adult Congenital Heart Disease And Pediatrics
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Kawasoe Yasutaka
Department Of Adult Congenital Heart Disease And Pediatric Cardiology Chiba Cardiovascular Center
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Niwa Koichiro
Department Of Adult Congenital Heart Disease And Pediatric Cardiology Chiba Cardiovascular Center
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Niwa Koichiro
Committee On Guideline For Prevention And Management Of Infective Endocarditis Japanese Circulation
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Ikeda Tomoaki
Department Of Obsterics And Gyneclogy Miyazaki Medical College University Of Miyazaki
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Ueda Keiko
Department Of Biosystems Science Graduate School Of Science And Technology Kobe University
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Neki Reiko
Department Of Perinatology National Cardiovascular Center
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Yamanaka Kaoru
Department Of Electronic Engineering Institute Of Vocational Training
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Niwa Koichiro
Departments Of Pediatrics Chiba Cardiovascular Center
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Katsuragi Shinji
Department Of Perinatology National Cardiovascular Center
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Sasaki Yoshihito
Department Of Obstetrics And Gynecology Asahikawa Medical College
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Neki Reiko
Department Of Perinatology And Gynecology National Cerebral And Cardiovascular Center
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UEDA Keiko
National Cerebral and Cardiovascular Center
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IKEDA Tomoaki
National Cerebral and Cardiovascular Center
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OSATO Kazuhiro
Departments of Perinatology and Gynecology, National Cerebral and Cardiovascular Center
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Osato Kazuhiro
Departments Of Perinatology And Gynecology National Cerebral And Cardiovascular Center
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Neki Reiko
Departments Of Perinatology And Gynecology National Cerebral And Cardiovascular Center
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Niwa Koichiro
National Cerebral And Cardiovascular Center
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Sasaki Yoshihito
Departments Of Perinatology And Gynecology National Cerebral And Cardiovascular Center
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IKEDA Tomoaki
Deparartment of Perinatology, National Cardiovascular Center
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UEDA Keiko
Deparartment of Perinatology, National Cardiovascular Center
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KATSURAGI Shinji
Deparartment of Perinatology, National Cardiovascular Center
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OSATO Kazuhiro
Department of Obstetrics and Gynecology, Department of Pathology, Faculty of Medicine, University of Miyazaki
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