Causative Organism Influences Clinical Profile and Outcome of Infective Endocarditis in Pediatric Patients and Adults With Congenital Heart Disease
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概要
- 論文の詳細を見る
Background Studies on microorganisms in a large cohort of patients with congenital heart disease (CHD) and infective endocarditis (IE) are rare. Using a nationwide survey, the relationship between causative microorganisms and clinical profiles in patients with CHD and IE was investigated. Methods and Results Data from 188 patients with CHD (pediatric patients (n=113), mean age, 6.2±4.9 years; adult patients (n=75), mean age 28.4±13.4 years) and IE from 60 institutions were analyzed. Causative microorganisms were Streptococcus species (94:50.0%), Staphylococcus species (68:36.2%), Haemophilus species (9:4.8%), Candida (5:2.7%), Pseudomonas species (4:2.1%) and other unclassified microorganisms (8:4.3%). Staphylococcal IE was observed significantly higher in perioperative IE (11/16), in cyanotic patients (32/73) and patients younger than 1 year old (11/16). Streptococcal IE was observed significantly higher in acyanotic patients (64/109) and patients aged 16 years or older (48/75). Total mortality was 20/188 (10.6%) and was high for candidial (2/5; 40%) and pseudomonal IE (2/4; 50%). Mortality was highly associated with younger age, especially infants (5/16), and methicillin-resistant staphylococcal IE (6/15). Conclusions The causative microorganisms are significantly related to the clinical profile and outcome in patients with IE and CHD. These results form the basis for selecting appropriate antibiotics for prevention and management.
- 社団法人日本循環器学会の論文
- 2005-09-20
著者
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Yoshinaga Masao
Department of Pediatrics, National Hospital Organization Kagoshima Medical Center
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Yoshinaga Masao
Division Of Pediatrics Graduate School Of Medical And Dental Sciences Kagoshima University
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Yoshinaga Masao
Kagoshima Med Ctr
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Yoshinaga Masao
Kagoshima Medical Center
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Tateno Shigeru
Department of Pediatrics, Chiba Cardiovascular Center
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Tateno Shigeru
Department Of Adult Chd Chiba Cardiovascular Center
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NIWA Koichiro
Department of Adult Congenital Heart Disease and Pediatric Cardiology, Chiba Cardiovascular Center
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TERAI Masaru
Departments of Pediatrics, Chiba University School of Medicine
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Nakazawa Makoto
Minami Tohoku Hospital
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Ishiwada Naruhiko
Department of Pediatrics, Chiba University Graduate School of Medicine
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Nakazawa Makoto
Division of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women's Medical University
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Tateno Shigeru
Department Of Adult Congenital Heart Disease And Pediatrics
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Niwa Koichiro
Department Of Adult Chd Chiba Cardiovascular Center
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Niwa Koichiro
Department Of Adult Congenital Heart Disease And Pediatrics
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Niwa Koichiro
Department Of Adult Congenital Heart Disease And Pediatric Cardiology Chiba Cardiovascular Center
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Niwa Koichiro
Committee On Guideline For Prevention And Management Of Infective Endocarditis Japanese Circulation
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Niwa Koichiro
Department Of Adult Congenital Heart Disease And Pediatrics Chiba Cardiovascular Center
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Tateno Shigeru
Department Of Adult Congenital Heart Disease And Pediatrics Chiba Cardiovascular Center
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Terai Masaru
Tokyo Women's Med Univ
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Terai Masaru
Department Of Pediatrics Chiba University School Of Medicine
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Terai Masaru
Department Of Pediatrics Graduate School Of Medicine Chiba University
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Yoshinaga Masao
Department Of Pediatrics Faculty Of Medicine Kagoshima University
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Tajimi Morihiro
Department Of Public Health Jichi Medical School
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Ishiwada Naruhiko
Department Of Hematology Japanese Red Cross Nagoya First Hospital
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Ishiwada Naruhiko
Department Of Pediatrics Chiba University Graduate School Of Medicine
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Nakazawa Makoto
Division Of Pediatric Cardiology
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Tateno Shigeru
Departments Of Pediatrics Chiba University School Of Medicine
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Niwa Koichiro
Departments Of Pediatrics Chiba Cardiovascular Center
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Nakazawa Makoto
The Gene Cardiovascular Disease Epidemiology Committee Of Japanese Pediatric Cardiology And Cardiac
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吉永 正夫
Department Of Pediatrics National Hospital Organization Kagoshima Medical Center
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Nakazawa Makoto
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women's Medical Universit
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Matsuda Yoshio
Department Of Obstetrics And Gynecology Maternal And Perinatal Center Maternal Division Tokyo Women's Medical University
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Ishiwada Naruhiko
Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine
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TERAI Masaru
Department of Pediatrics and Pediatric Intensive Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center
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