Impairment of Angiogenic Activity in the Serum From Patients With Coronary Aneurysms Due to Kawasaki Disease

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概要

• 論文の詳細を見る

• Background The inflammatory mediators play an important role in the progression of coronary vasculitis in Kawasaki disease (KD), but effects of KD serum including inflammatory mediators on endothelial cells remain unknown. We hypothesized that serum activity to stimulate in vitro human umbilical vein endothelial cells (HUVEC) tube formation might be impaired in KD. Methods and Results Serum from patients with coronary aneurysms was less active in stimulating HUVEC tube formation than serum from patients without coronary aneurysms or febrile controls. In patients with coronary aneurysms, the reduction in the serum angiogenic activity was documented already before KD treatment (p=0.03 vs healthy controls, p=0.08 vs febrile controls) and enhanced after intravenous immune globulin plus aspirin (p<0.001 vs healthy controls, p=0.002 vs febrile controls); both drugs did not affect the assay studied. This reduction was greater in patients who later developed giant aneurysms >8 mm compared with those who developed small to moderate aneurysms (p=0.01). The reduced serum angiogenic activity was partly caused by the reduction in the serum activity of stimulating HUVEC proliferation. Conclusions Serum activity to stimulate HUVEC tube formation was impaired in KD patients who later developed larger coronary aneurysms, which may be associated with the severity of vascular injury.

• 社団法人日本循環器学会の論文
• 2007-06-20

著者

• TERAI Masaru

  Departments of Pediatrics, Chiba University School of Medicine

• Kohno Yoichi

  Department Of Pediatrics Graduate School Of Medicine Chiba University

• Kohno Yoichi

  Department Of Pediatrics Chiba University Graduate School Of Medicine

• Hamada Hiromichi

  Department of Pediatrics, Graduate School of Medicine, Chiba University

• KANAZAWA Masaki

  Department of Pediatrics, Chiba University Graduate School of Medicine

• Terai Masaru

  Tokyo Women's Med Univ

• Terai Masaru

  Department Of Pediatrics Chiba University School Of Medicine

• Terai Masaru

  Department Of Pediatrics Graduate School Of Medicine Chiba University

• Hamada Hiromichi

  Department Of Pediatrics Graduate School Of Medicine Chiba University

• HONDA Takafumi

  Department of Pediatrics, Faculty of Medicine, University of Chiba

• Tajimi Morihiro

  Department Of Public Health Jichi Medical School

• Honda Takafumi

  Department Of Pediatrics Graduate School Of Medicine Chiba University

• Honda Takafumi

  Department Of Pediatrics Faculty Of Medicine University Of Chiba

• HIGASHI Kouji

  Department of Electronics, Miyazaki University

• Kanazawa Masaki

  Department Of Internal Medicine Kofu Municipal Hospital

• Higashi Kouji

  Department Of Pediatrics Graduate School Of Medicine Chiba University

• Higashi Kouji

  Department Of Electronics Miyazaki University

• Hamada Hiromichi

  Department Of Pediatrics Tokyo Women's Medical University Yachiyo Medical Center

• TERAI Masaru

  Department of Pediatrics and Pediatric Intensive Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center

• HONDA Takafumi

  Department of Pediatrics and Pediatric Intensive Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center

• HAMADA Hiromichi

  Department of Pediatrics and Pediatric Intensive Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center

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