Prenatal Vitamin E Treatment Improves Lung Growth in Fetal Rats with Congenital Diaphragmatic Hernia

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概要

• 論文の詳細を見る

• The aim of this study was to test the effects of vitamin E on fetal lung growth in rats with congenital diaphragmatic hernia (CDH). Experimental congenital diaphragmatic hernia (CDH) was induced in rat fetuses by maternal administration of 100 mg nitrofen by gastric gavage on day 9.5 of gestation. Vitamin E was provided at days 16-20 of gestation, at 30 IU/day. Cesarean section was performed at day 21 of gestation. Immunohistochemistry was performed using anti-surfactant protein A (SP-A) and anti-SP-B polyclonal antibodies. RT-PCR evaluated SP-A and SP-B mRNA expressions. The lung weight/body weight ratio in rats with CDH was lower than the control (p<0.01). The number of type II pneumocytes positive for SP-A in untreated CDH rats (n=20) was lower than the control (n=20). The relative amounts of SP-A and SP-B were significantly higher in vitamin Etreated CDH rats (n=20) than untreated CDH rats (p<0.05). Our results suggest that antenatal vitamin E treatment increases the production of surfactant proteins in hypoplastic lung of rats with the CDH.

• 長崎大学の論文

著者

• Masuzaki Hideaki

  長崎大学 大学院医歯薬学総合研究科産婦人科

• Masuzaki Hideaki

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• Nakayama Daisuke

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• Nakayama Daisuke

  長崎大学 大学院医歯薬学総合研究科産婦人科

• Yoshimura Shuichiro

  長崎大学 医歯薬学総合研究科人類遺伝学

• YOSHIMURA Shuichiro

  Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences

• Ishimaru Tadayuki

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• YOSHIDA Shigo

  Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences

• Kitajima Michio

  Department Of Obstetrics And Gynecology

• Minakami Hisanori

  Department Of Obstetrics And Gynecology Graduate School Of Medicine Hokkaido University

• Yoshimura Shuichiro

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• Yoshimura Shuichiro

  Department Of Obstetrics And Gynecology Asahikawa Medical College

• Sasaki Yoshihito

  Department Of Obstetrics And Gynecology Asahikawa Medical College

• Yoshida Atsushi

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

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