A 1.5-Mb PAC/BAC Contig Spanning the Prader-Willi Syndrome Critical Region (PWCR)

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概要

• 論文の詳細を見る

• Prader-Willi syndrome (PWS) is a multiple anomalies/mental retardation syndrome. The putative PWS gene(s) remains unknown, and its occurrence is based on genomic imprinting at chromosome 15q11-q13. We have constructed a 1.5- Mb, fine, physical map of PWS critical region (PWCR) between two markers, D15S9 and D15S174 at 15q11-q13. The map is composed of 32 PAC and 3 BAC clones without any gaps. By the PAC/BAC-end sequencing procedure, a total of 26 sequence tag site (STS) markers were newly generated, and 5 expressed sequence tags (ESTs) were mapped in the region. The contig map was verified by both STS and fluorescence in situ hybridization analyses. Our map has higher resolution, compared with a previous YAC-based map of PWCR. It is useful for further genome analysis, especially on genomic imprinting of this region.

• 長崎大学の論文

著者

• Kishino T

  Department Of Pediatrics Nagasaki University School Of Medicine

• Kondoh Tatsuro

  長崎大学 医学部小児科

• Kondoh Tatsuro

  長崎大学 看

• Kondoh Tatsuro

  長崎大学 医歯薬学研究科人類遺伝学

• Kondoh Tatsuro

  東北大学 医学部遺伝病学分野

• Yoshiura Koh-ichiro

  長崎大学 医歯薬学総合研究科人類遺伝学

• Yoshiura Koh‐ichiro

  Jst‐sorst Kawaguchi Jpn

• Niikawa Norio

  長崎大学 医歯薬学総合研究科人類遺伝学

• Niikawa N

  The Research Institute Of Personalized Health Sciences Health Sciences University Of Hokkaido

• KONDO Shinji

  Department of Pediatrics, The University of Iowa, Iowa City

• Matsumoto Naomichi

  長崎大学 医歯薬学研究科人類遺伝学

• Yoshimura Shuichiro

  長崎大学 医歯薬学総合研究科人類遺伝学

• Kondo Shinji

  Division Of Functional Genomics Center For Frontier Life Sciences Nagasaki University

• Kondoh Shinji

  長崎大学 大学院生物医学科学

• Kudo T

  Department Of Medical Genetics Tohoku University School Of Medicine

• Tomita Hiro-Aki

  Department of Plastic and Reconstructive Surgery, Nagasaki University School of Medicine

• Kishino Tatsuya

  Department of Ophthalmology, Nagasaki University School of Medicine

• Yoshiura Koh-ichiro

  RIKEN Gene Bank, Institute of Physical and Chemical Research

• Yamada Koki

  Department of Human Genetics, University of Chicago

• Soeda Eiichi

  Department of Genetics, Case Western Reserve University

• Kudo Takayuki

  Department Of Otorhinolaryngology Tohoku University School Of Medicine

• Ohta T

  Sorst Japan Science And Technology Agency

• YAMASAKI Kentaro

  Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences

• Kayashima Tomohiko

  Department Of Human Genetics Nagasaki University School Of Medicine

• Tomita Hiro-aki

  Nagasaki Prefectural Medical Health Center

• Yamada Koki

  Department Of Human Genetics University Of Chicago

• Soeda Eiichi

  Department Of Applied Microbial Technology Kumamoto Institute Of Technology

• Soeda Eiichi

  Department Of Genetics Case Western Reserve University

• Tomita Hiro-aki

  Department Of Physiology And Biophysics Med Sci I D-335 University Of California

• Yoshiura Koh-ichiro

  Department Of Human Genetics Nagasaki University Graduate School Of Biomedical Sciences

• Kondoh Tatsuro

  Department Of Pediatrics Nagasaki University Graduate School Of Biomedical Sciences

• Kondo Shinji

  Department Of Pediatrics The University Of Iowa Iowa City

• Ozawa Hiroki

  Department Of Psychiatry Nagasaki University Hospital

• Tomita Hiroaki

  Department Of Biological Psychiatry Tohoku University Graduate School Of Medicine

• Yoshiura Kohichiro

  RIKEN Gene Bank, Institute of Physical and Chemical Research

• KONDO Shinji

  Department of Applied Chemistry, Muroran Institute of Technology

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