A type of familial cleft of the soft palate maps to 2p24.2–p24.1 or 2p21–p12

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概要

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• Cleft of the soft palate (CSP) and the hard palate (CHP) are subtypes of cleft palate. Patients with either condition often have difficulty with speech and swallowing. Nonsyndromic, cleft palate isolated has been reported to be associated with several genes, but to our knowledge there have been no detailed genetic investigations of CSP. We performed a genome-wide linkage analysis using an SNP-based microarray platform and successively using microsatellite markers in a family where six members, across three successive generations, had CSP. A maximum LOD score of 2.408 was obtained at 2p24.2-24.1 and 2p21-p12, assuming autosomal dominant inheritance. Our results suggest that either of these regions is responsible for this type of CSP.

• Japan Society of Human Geneticsの論文
• 2010-02-01

著者

• Kishino T

  Department Of Pediatrics Nagasaki University School Of Medicine

• Kondoh Tatsuro

  長崎大学 医学部小児科

• Kondoh Tatsuro

  長崎大学 看

• Kondoh Tatsuro

  長崎大学 医歯薬学研究科人類遺伝学

• Kondoh Tatsuro

  東北大学 医学部遺伝病学分野

• Yoshiura Koh-ichiro

  長崎大学 医歯薬学総合研究科人類遺伝学

• Yoshiura Koh‐ichiro

  Jst‐sorst Kawaguchi Jpn

• Kinoshita Akira

  長崎大学 医歯薬学総合研究科人類遺伝学

• Kinoshita Akira

  長崎大学 医歯薬学研究科人類遺伝学

• Niikawa Norio

  長崎大学 医歯薬学総合研究科人類遺伝学

• Niikawa N

  The Research Institute Of Personalized Health Sciences Health Sciences University Of Hokkaido

• Masuzaki Hideaki

  長崎大学 大学院医歯薬学総合研究科産婦人科

• Masuzaki Hideaki

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• Matsumoto Tadashi

  Department Of Pediatrics Nagasaki University School Of Medicine

• Yoshimura Shuichiro

  長崎大学 医歯薬学総合研究科人類遺伝学

• Kinoshita A

  Tokyo Denki Univ. Hiki Jpn

• KISHINO Tatsuya

  Division of Functional Genomics, Center for Frontier Life Sciences, Nagasaki University

• NAKASHIMA Mitsuko

  Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences

• Kudo T

  Department Of Medical Genetics Tohoku University School Of Medicine

• Yamada Takahiro

  Department Of Obstetrics And Gynecology Hokkaido University Graduate School Of Medicine

• Kudo Takayuki

  Department Of Otorhinolaryngology Tohoku University School Of Medicine

• Matsuzaka Tetsuo

  Division Of Pediatrics Nagasaki Prefectural Center Of Medicine And Welfare For Children

• Matsuzaka Tetsuo

  Department Of Pediatrics Nagasaki University School Of Medicine

• Minakami Hisanori

  Department Of Gynecology Hokkaido University

• Minakami Hisanori

  Department Of Obstetrics And Gynecology Graduate School Of Medicine Hokkaido University

• Kayashima Tomohiko

  Department Of Human Genetics Nagasaki University School Of Medicine

• Matsumoto Tadashi

  Genetic Counseling Unit Nagasaki University Hospital

• Yamada Takahiro

  Department Of Applied Chemistry School Of Engineering Tohoku University

• Tagawa Masato

  Department Of Pediatrics Nagasaki University Hospital

• Tashiro Kasumi

  Department Of Pediatrics Nagasaki University School Of Medicine

• Yoshiura Koh-ichiro

  Department Of Human Genetics Nagasaki University Graduate School Of Biomedical Sciences

• Nakashima Mitsuko

  Department Of Human Genetics Nagasaki University Graduate School Of Biomedical Sciences

• Kondoh Tatsuro

  Department Of Pediatrics Nagasaki University Graduate School Of Biomedical Sciences

• Hirano Akiyoshi

  Division Of Plastic And Reconstructive Surgery Nagasaki University Graduate School Of Biomedical Sci

• Kinoshita Akira

  Department Of Applied Science Faculty Of Engineering Tokyo Electrical Engineering College

• Kinoshita Akira

  Department Of Human Genetics Nagasaki University Graduate School Of Biomedical Sciences

• Matsumoto Tadashi

  Division Of Pediatrics Nagasaki Prefectural Center Of Medicine And Welfare For Children

• Kimura Akitsugu

  Department Of Materials Sciene And Engineering National Defense Academy

• Matsumoto Tadashi

  School Of Allied Medical Sciences Nagasaki University

• Niikawa Norio

  Research Institute Of Personalized Health Sciences Health Sciences University Of Hokkaido

• TSUDA Masayoshi

  Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences

• MIKOYA Tadashi

  Center for Advanced Oral Medicine, Hokkaido University Hospital

• SOGABE Izumi

  Department of Maxillofacial Surgery, Hokkaido University Graduate School of Medicine

• HIRANO Akiyoshi

  Department of Plastic and Reconstructive Surgery, Nagasaki University Graduate School of Biomedical Sciences

• Sogabe Izumi

  Department Of Maxillofacial Surgery Hokkaido University Graduate School Of Medicine

• Hirano Akiyoshi

  Department Of Plastic And Reconstructive Surgery Nagasaki University Graduate School Of Biomedical Sciences

• Tsuda Masayoshi

  Department Of Human Genetics Nagasaki University Graduate School Of Biomedical Sciences

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