Histological and Immunohistochemical Analysis of Fetal Hypoplastic Lungs: Preliminary Study

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概要

• 論文の詳細を見る

• To investigate cellular growth and differentiation of the airway epithelium of the human fetal lung using immunohistochemistry, with a particular focus on cases of pulmonary hypoplasia. A total of 25 autopsy cases of stillbirth and early neonatal death were examined at Nagasaki University Hospital from 1986 to 1997. Using immunohistochemistry, we determined the expression of a variety of growth factors (EGFR, HGFR, GRP and SAPA) in lung tissues with or without pulmonary hypoplasia. A significant decrease in radial alveolar count was detected in hypoplastic lungs compared with normal lungs. The expressions of EGFR, HGFR and GRP in tissues from hypoplastic lungs were significantly lower than in tissues from normal lungs, but the expression of SAPA was not different between the two groups. Our results indicated that significant abnormalities of cellular growth and differentiation are present in pulmonary hypoplasia. However, lung maturation in pulmonary hypoplasia was not significantly different to that in normal lungs.

• 長崎大学の論文

著者

• Masuzaki Hideaki

  長崎大学 大学院医歯薬学総合研究科産婦人科

• Masuzaki Hideaki

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• Yoshimura Shuichiro

  長崎大学 医歯薬学総合研究科人類遺伝学

• MIURA Kiyonori

  Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences

• YOSHIMURA Shuichiro

  Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences

• Ishimaru Tadayuki

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• YOSHIDA Shigo

  Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences

• Minakami Hisanori

  Department Of Obstetrics And Gynecology Graduate School Of Medicine Hokkaido University

• Fujishita Akira

  Nagasaki University Nagasaki Municipal Hospital

• Miura Kiyonori

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• Yoshimura Shuichiro

  Department Of Obstetrics And Gynecology Nagasaki University Graduate School Of Biomedical Sciences

• Yoshimura Shuichiro

  Department Of Obstetrics And Gynecology Asahikawa Medical College

• Sasaki Yoshihito

  Department Of Obstetrics And Gynecology Asahikawa Medical College

• Miura Kiyonori

  長崎大学 大学院医歯薬学総合研究科産科婦人科学

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