Ki-67 Labeling Index Is Associated with Recurrence after Segmentectomy under Video-assisted Thoracoscopic Surgery in Stage I Non-small Cell Lung Cancer
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概要
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Objectives: Video-assisted thoracoscopic surgery (VATS) segmentectomy for small or early stage non-small cell lung cancer (NSCLC) remains controversial. Here, we investigated the clinical importance of predicting recurrence by Ki-67 in VATS segmentectomy for stage I NSCLC.Methods: In a retrospective study, 44 consecutive patients in p-stage I underwent VATS segmentectomy between September 2003 and April 2009. After clinicopathological factors were compared with Ki-67 expression, the relationship between Ki-67 labeling indexes (LI) or mRNA expression by quantitative RT-PCR and prognosis was investigated.Results: Five of 44 VATS segmentectomy patients relapsed. In the relapsed patients, 3 (6.8%) were local recurrences and 2 (4.5%) were distant metastases. There was no significant difference between clinicopathological factors and recurrence; however, patients with Ki-67 LI less than 5% showed better disease-free survival than patients with Ki-67 LI over 5% (p = 0.04). In multivariate Cox regression analysis, although there was no significantly different in disease-free survival by age, histology, tumor size, only Ki-67 LI showed a significant prognostic factor of recurrence (HR = 12.5, 95% CI = [1.1-1407], p = 0.04).Conclusions: Ki-67 LI after VATS segmentectomy was a prognostic factor of disease-free survival in NSCLC and the treatment of choice for patients with positive LI may be considered, in addition to adjuvant chemotherapy, or lobectomy.
- Annals of Thoracic and Cardiovascular Surgery 編集委員会の論文
- 2011-08-01
著者
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Yamashita Shin-ichi
Department Of Oncological Science (surgery 2) Oita University Faculty Of Medicine
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Chujo Masao
Department Of Oncological Science Surgery Ii Oita University Faculty Of Medicine
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Chujo Masao
Department Of Oncological Science (surgery 2) Oita University Faculty Of Medicine
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Kawahara Katsunobu
Department Of Oncological Science (surgery 2) Oita University Faculty Of Medicine
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Kawahara Katsunobu
Department Of Surgery Ii Faculty Of Medicine Oita University
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Yamamoto Satoshi
Department Of Biochemistry Nagoya University School Of Medicine
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Miyawaki Michiyo
Department Of Oncological Science (surgery 2) Oita University Faculty Of Medicine
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MOROGA Toshihiko
Department of Surgery II, Faculty of Medicine, Oita University
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TOKUISHI Keita
Department of Surgery II, Faculty of Medicine, Oita University
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Moroga Toshihiko
Department Of Surgery Ii Faculty Of Medicine Oita University
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Tokuishi Keita
Department Of Surgery Ii Faculty Of Medicine Oita University
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Yamamoto Satoshi
Department Of Surgery Ii Faculty Of Medicine Oita University
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Kawahara Katsunobu
Department of Surgery II, Faculty of Medicine, Oita University
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