Distribution of Langerhans Cells in the Human Esophagus, as Revealed by Immunohistochemistry
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概要
- 論文の詳細を見る
Our previous report illustrated that the epithelium of the human esophagus has numerous lymphocytes and Langerhans cells with Birbeck granules. In the present study, the distribution of Langerhans cells in the human esophagus was examined immunohistochemically. The human esophageal specimens were obtained by the surgery for esophageal carcinoma with informed consent. The tissue blocks were fixed with 10% formalin and embedded in paraffin. The thin sections were treated with anti-S-100 protein antibody, placed in lgG-gold (5nm) solution as a second antibody, and then sensitized with the physical development method. The Langerhans cells, which showed a positive immunoreaction for the S-100, were distributed within the epithelium throughout the esophagus. Their distribution patterns differed according to the region of the esophagus. The Langerhans cells tended to increase in number as they moved further from the oral cavity toward the abdominal part. In this study, it was suggested that they played important roles in the immune response of the human esophagus.
- 日本組織細胞化学会の論文
著者
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島田 達生
Oita University Department Of Anatomy Biology And Medicine
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島田 達生
Department Of Anatomy Oita Medical University
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Shimada T
Department Of Anatomy Biology And Medicine Faculty Of Medicine Oita University
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KAWAHARA Katsunobu
Department of Surgery II, Oita University Faculty of Medicine
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NAGAI Kaoruko
Department of Anatomy, Oita Medical University
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Shimada Tatsuo
Department Of Anatomy Biology And Medicine Faculty Of Medicine Oita University
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Noguchi Tsuyoshi
Department Of Oncological Science (surgery Ii) School Of Medicine Oita University
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Noguchi Tsuyoshi
Department Of Gastrointestinal Surgery Oita University Faculty Of Medicine
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Nagai Kaoruko
Department Of Oncological Science (surgery Ii) School Of Medicine Oita University
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Nagai Kaoruko
Department Of Anatomy Oita Medical University
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Fujiwara Shozo
Department Of Oncological Science (surgery Ii) School Of Medicine Oita University
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Kawahara Katsunobu
Department Of Oncological Science (surgery Ii) School Of Medicine Oita University
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Kawahara Katsunobu
Department Of Oncological Science (surgery 2) Oita University Faculty Of Medicine
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Noguchi Tsuyoshi
Second Department Of Surgery Oita Medical University
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Sakai Takashi
大分大学 医学部皮膚科･形成外科
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