Preliminary Calculation of RBE-weighted Dose Distribution for Cerebral Radionecrosis in Carbon-ion Treatment Planning

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概要

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• Cerebral radionecrosis is a significant side effect in radiotherapy for brain cancer. The purpose of this study is to calculate the relative biological effectiveness (RBE) of carbon-ion beams on brain cells and to show RBE-weighted dose distributions for cerebral radionecrosis speculation in a carbon-ion treatment planning system. The RBE value of the radionecrosis for the carbon-ion beam is calculated by the modified microdosimetric kinetic model on the assumption of a typical clinical α/β ratio of 2 Gy for cerebral radionecrosis in X-rays. This calculation method for the RBE-weighted dose is built into the treatment planning system for the carbon-ion radiotherapy. The RBE-weighted dose distributions are calculated on computed tomography (CT) images of four patients who had been treated by carbon-ion radiotherapy for astrocytoma (WHO grade 2) and who suffered from necrosis around the target areas. The necrotic areas were detected by brain scans via magnetic resonance imaging (MRI) after the treatment irradiation. The detected necrotic areas are easily found near high RBE-weighted dose regions. The visual comparison between the RBE-weighted dose distribution and the necrosis region indicates that the RBE-weighted dose distribution will be helpful information for the prediction of radionecrosis areas after carbon-ion radiotherapy.

• 2011-11-16

著者

• HASEGAWA Azusa

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• Kanai T

  Department Of Accelerator And Medical Physics National Institute Of Radiological Sciences

• Kanai Tatsuaki

  茨城県立医療大学 放射線技術科学科

• Hiraoka Takeshi

  Nirs

• KANAI Tatsuaki

  NIRS

• MINOHARA Shinichi

  Div. Accelerator Phys. Eng.

• Minohara Shinichi

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• Kanai Tatsuaki

  Department Of Accelerator And Medical Physics Research Center For Charged Particle Therapy National

• Kanai Tatsuaki

  Department Of Medical Physics National Institute Of Radiological Sciences

• Mori Shinichiro

  Department Of Accelerator And Medical Physics Research Center For Particle Therapy National Institut

• Kamata Tadashi

  Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences

• Matsufuji Naruhiro

  Department Of Accelerator And Medical Physics Research Center For Charged Particle Therapy National

• Matsufuji Naruhiro

  Department Of Accelerator Physics And Engineering National Institute Of Radiological Sciences

• Hasegawa Azusa

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Matsufuji Naruhiro

  Div. Of Accel. Phys. And Eng. Nat'l. Inst. Of Radiol. Sci.

• Kanai Tatsuaki

  Div. Acce. Res. Natl. Inst. Radiol Sci.

• Himukai Takeshi

  筑波大学数理物質科学研究科電子・物理工学専攻

• Minohara Shinichi

  Research Center For Particle Therapy National Institute Of Radiological Sciences

• Tameshige Yuji

  Office For Development Of Proton Therapy Center Regional Health Services Division Department Of Heal

• Matsufuji Naruhiro

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Kase Yuki

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Kanai Tatsuaki

  Heavy Ion Medical Center Gunma Univ.

• Himukai Takeshi

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Mizoe Junetsu

  Cnao Foundation National Center For Oncological Hadrontherapy

• NAGANO Ai

  Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

• TAMESHIGE Yuji

  Proton Therapy Center, Fukui Prefectural Hospital

• FOSSATI Piero

  CNAO Foundation, National Center for Oncological Hadrontherapy

• Nagano Ai

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Fossati Piero

  Cnao Foundation National Center For Oncological Hadrontherapy

• Minohara Shinichi

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

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