Determination of Branched β-Cyclodextrin-Prostaglandin Complexes Using Electrospray Ionization Mass Spectrometry
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概要
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Mass spectral measurements by electrospray ionization mass spectrometry (ESI-MS) detected the ions of β-cyclodextrin (βCD) or branched βCDs (glucosyl-, galactosyl-, mannosyl- and maltosyl-βCD)–prostaglandins (PGs: PGA2, PGD2, PGE1, PGE2, PGF2α and PGJ2) complexes, i.e., βCD–PG complexes, with a host:guest ratio of 1:1 in the negative ion mode. This is the first study to report the ions of branched βCD–PG complexes using ESI-MS. The inclusion complexes were determined by a flow injection analysis using acetonitrile/water. We could confirm by this method the presence of a βCD–PGE2 complex with a host:guest ratio of 1:1 in a solution-dissolved pharmaceutical formulation consisting of βCD–PGE2 (ProstarmonTM E tablet).
- 社団法人 日本農芸化学会の論文
- 2008-08-23
著者
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Honda Chie
School Of Pharmaceutical Sciences Mukogawa Women's University
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YAMANE Naoe
JCL Bioassay Corporation
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TOZUKA Zenzaburo
JCL Bioassay Corporation
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Tanimoto Toshiko
School Of Pharmaceutical Science Mukogawa Women's University
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Nishi Yuki
School Of Pharmaceutical Sciences Mukogawa Women's Univ.
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Okada Yasuyo
School Of Pharmaceutical Sciences Mukogawa Women's Univ.
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Tanimoto Toshiko
School Of Pharmaceutical Sciences Mukogawa Women's Univ.
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