Some Properties and the Inclusion Behavior of Three Positional Isomers of 6^1,6^n-Di-O-α-D-glucosyl-cyclomaltoheptaoses (β-Cyclodextrins)
スポンサーリンク
概要
- 論文の詳細を見る
Three positional isomers of 6^1,6^n-di-O-α-D-glucosyl-cyclomaltoheptaose [1,n-(G)_2-βCDs; n=2-4] which existed in the digests with glucoamylase of the products from cyclomaltoheptaose (β-cyclodextrin, βCD) and maltose with Klebsiella pneumoniae pullulanase, were purified by HPLC. The solubilities of two isomers of those doubly branced βCDs, 1,2- and 1,3-(G)_2-βCDs, in water were much higher than those of parent non-branched βCD and mono-branched βCD, 6-O-α-D-glucosyl-βCD (G-βCD), while the solubility of another isomer, 1,4-(G)_2-βCD, was significantly lower than these two isomers, though it was higher than that of βCD. On the other hand, the solubilities of 1,2- and 1,3-isomers in 10,30,and 50% (v/v) aqueous methanol at 25℃ were independent of methanol concentrations and their solubilities were the same as those in water at 25℃. However, that of 1,4-isomer increased with increasing methanol concentrations. The hemolytic activities of 1,n-(G)_2-βCDs on human erythrocytes in isotonic solution were lower than those of G-βCD and βCD, and became weaker in the order of 1,4->1,2->1,3-isomers. The complex-forming abilities of 1,n-(G)_2-βCDs for digitoxin, digoxin, fluorometholone, flurbiprofen, hydrocortisone acetate, and norfloxacin were about the same as those of βCD and G-βCD, whereas reserpine was more difficult to include within 1,n-(G)_2-βCDs than βCD and G-βCD. Nevertheless, the solubilities of those guest compounds were much more enhanced by 1,n-(G)_2-βCDs and G-βCD than by βCD.
- 公益社団法人日本薬学会の論文
- 1998-02-15
著者
-
Okada Yasuyo
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Womens University
-
KOIZUMI Kyoko
School of Pharmaceutical Sciences, Mukogawa Women's University
-
Koizumi Kyoko
School Of Pharmaceutical Sciences Mukogawa Women's University
-
Okada Yasuyo
School Of Pharmaceutical Sciences Mukogawa Women's University
-
Okada Yasuyo
School Of Pharmaceutical Sciences Mukogawa Women's Univ.
関連論文
- Negative and Positive Ion Mode LC/MS/MS for Simple, Sensitive Analysis of Sorbic Acid
- Absorption, Distribution and Excretion of β-Cyclodextrin and Glucosyl-β-cyclodextrin in Rats
- Sensitive and Simple Analysis of Sorbic Acid Using Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry
- Properties and the Inclusion Behavior of 6-O-α-D-Galactosyl- and 6-O-α-D-Mannosyl-cyclodextrins
- Enzymatic Synthesis of N-Acetylglucosaminyl-cyclodextrin by the Reverse Reaction of N-Acetylhexosaminidase from Jack Bean
- Preparation and Characterization of Novel Branched β-Cyclodextrins Having β-D-Galactose Residues on the Non-reducing Terminal of the Side Chains and Their Specific Interactions with Peanut (Arachis hypogaed) Agglutinin
- Synthesis of Novel Heterobranched β-Cyclodextrins from α-D-Mannosyl Maltotriose and β-Cyclodextrin by the Reverse Action of Pullulanase, and Isolation and Characterization of the Products
- Synthesis of Novel Heterobranched β-Cyclodextrins from 4^2-O-β-D-Galactosyl-Maltose and β-Cyclodextrin by the Reverse Action of Pullulanase, and Isolation and Characterization of the Products
- Enzymatic Synthesis of Mannosyl-cyclodextrin by α-Mannosidase from Jack Bean
- HPLC Analysis of Manno-Oligosaccharides Derived from Saccharomyces cerevisiae Mannan Using an Amino Column or a Graphitized Carbon Column
- Some Properties and the Inclusion Behavior of Three Positional Isomers of 6^1,6^n-Di-O-α-D-glucosyl-cyclomaltoheptaoses (β-Cyclodextrins)
- Avsorption, Distribution and Excretion of Galactosyl-β-cyclodextrin and Mannosyl-β-cyclodextrin in Rats
- Determination of Branched β-Cyclodextrin-Prostaglandin Complexes Using Electrospray Ionization Mass Spectrometry