Avsorption, Distribution and Excretion of Galactosyl-β-cyclodextrin and Mannosyl-β-cyclodextrin in Rats
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概要
- 論文の詳細を見る
Microanalytical methods were developed for measuring galactosyl-β-cyclodextrin (Gal-βCD) and mannosyl (Man)-βCD in biological matrices of the rat by HPLC with pulsed amperometric detection. Then, using these methods, the absorption, distribution and excretion of intravenously and orally administered Gal-βCD and Man-βCD were determined in rats, and compared with those of glucosyl (Glc)-βCD. The pharmacokinetic behavior of Gal-βCD, Man-βCD and Glc-βCD after intravenous administration (50 mg/kg) was very similar. Within 6 h after intravenous administration, unchanged Gal-βCD and Man-βCD recovered in urine accounted for about 90% of each dose. After oral administration (500 mg/kg), 0.37% and 0.38% of Gal-βCD and Man-βCD, respectively, were excreted in urine. After intravenous and oral administration of Gal-βCD and Man-βCD, the decomposition of Gal-βCD and Man-βCD to βCD in the urine, kidney and liver was greater thn that of Glc-βCD. The sum of the molar concentrations of branced CDs and their decomposition product, βCD, in the liver at 4 h ater intravenous administration of Gal-βCD and Man-βCD was greater than that of Glc-βCD. Furthermore, the inclusion complexes of estriol and betamethasone with Gal-βCD, Man-βCD and Glc-βCD were prepared ant their absorption was evaluated after oral administration in rats. The plasma concentrations of the drugs after oral administration of drug-Gal-βCD and drug-Man-βCD complexes were the same as those after the administration of drug-Glc-βCD complexes.
- 公益社団法人日本薬学会の論文
- 2000-04-01
著者
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Koizumi Kyoko
School Of Pharmaceutical Sciences Mukogawa Women's University
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Kubota Yoko
School Of Pharmaceutical Sciences Mukogawa Women's University
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SANBE Haruyo
School of Pharmaceutical Sciences, Mukogawa Women's University
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Sanbe H
School Of Pharmaceutical Sciences Mukogawa Women's University
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Sanbe Haruyo
School of Pharmaceutical Sciences, Mukogawa Women's University
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