Proliferation and Differentiation of Cultured MC3T3-E1 Osteoblasts on Surface-layer Modified Hydroxyapatite Ceramic with Acid and Heat Treatments
スポンサーリンク
概要
- 論文の詳細を見る
Effects of functionally gradient calcium phosphate consisting of hydroxyapatite (HAP) and α-tricalcium phosphate (α-TCP) on proliferation and differentiation of osteoblasts were evaluated using MC3T3-E1 cells. There were no significant differences in the proliferation of MC3T3-E1 cells among HAP-α-TCP functionally gradient calcium phosphate, pure HAP, and cell culture plastic wells. mRNA expressions of type I collagen, alkaline phosphate, and osteocalcine were evaluated as indexes of initial, mid-stage, and late-stage osteoblastic differentiation. Basically, HAP-α-TCP functionally gradient calcium phosphate and pure HAP enhanced the expressions of the three markers when compared with that of cell culture plastic wells. For type I collagen and alkaline phosphate expressions, HAP-α-TCP functionally gradient calcium phosphate showed the same expression level as pure HAP. For osteocalcine expression, HAP-α-TCP functionally gradient calcium phosphate showed a higher level than pure HAP. We concluded, therefore, HAP-α-TCP functionally gradient calcium phosphate has good potential to be a bone filler material with high osteoconductivity.
- 日本歯科理工学会の論文
著者
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YUASA Tetsuya
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tok
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Ishikawa Kunio
Department Of Biomaterials Faculty Of Dental Science Kyushu University
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Ishikawa Kunio
九州大学 歯学部口腔機能修復学講座
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Yuasa T
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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TAKANO Hideyuki
Department of Applied Chemistry, Faculty of Engineering, Ehime University
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KON Masayuki
Department of Dental Engineering, School of Dentistry, Tokushima University
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Kon Masayuki
Department Of Biomaterials And Bioengineering Course Of Maxillo-oral And Regenerative Medicine Insti
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Miyamoto Youji
Dep. Of Therapic Regulation For Oral Tumors Inst. Of Health Biosciences The Univ. Of Tokushima Gradu
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Miyamoto Youji
Division Of Dentistry And Oral Surgery School Of Medicine Akita University
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Ishikawa Kunio
Department Of Biomaterials
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Ishikawa K
Department Of Biology And Geosciences Faculty Of Science National University Corporation Shizuoka Un
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NAGAYAMA Masaru
Department of Oral Surgery, Nagoya University School of Medicine, Nagoya
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Nagayama Masaru
Department Of Oral And Maxillofacial Surgery Institute Of Health Biosciences The University Of Tokus
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TAKECHI Masaaki
Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Graduate School
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MOMOTA Yukihiro
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tok
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TATEHARA Seiko
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tok
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MIMAMIGUCHI Shiho
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tok
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Kon Masayuki
徳島大学 歯 歯理工
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Yuasa Tetsuya
Dep. Of Oral And Maxillofacial Surgery Inst. Of Health Biosciences The Univ. Of Tokushima Graduate S
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Yuasa Tetsuya
Department Of Dermatology Mie University School Of Medicine
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Miyamoto Y
Division Of Cardiovascular Surgery And Anesthesiology Sakurabashi-watanabe Hospital
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Miyamoto Youji
Division Of Dentistry And Oral Surgery Akita University School Of Medicine
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Tatehara Seiko
Department Of Oral And Maxillofacial Surgery Institute Of Health Biosciences The University Of Tokus
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Kon M
Department Of Biomaterials And Bioengineering Course Of Maxillo-oral And Regenerative Medicine Insti
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Kon Masayuki
Department Of Dental Engineering School Of Dentisby Tokushima University
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Takechi Masaaki
Department Of Oral And Maxillofacial Surgery Division Of Cervico-gnathostomatology Graduate School O
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Takano Hideyuki
Department Of Oral And Maxillofacial Surgery Institute Of Health Biosciences The University Of Tokus
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Takano Hideyuki
Department Of Applied Chemistry Faculty Of Engineering Ehime University
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Mimamiguchi Shiho
Department Of Oral And Maxillofacial Surgery Institute Of Health Biosciences The University Of Tokus
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Takano H
Department Of Biological Sciences Faculty Of Science Kumamoto University
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Takechi M
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
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Momota Y
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
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Tatehara S
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
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Mimamiguchi S
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
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Nagayama M
Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
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