Effect of electrical stimulation of vagal afferents on trigeminal nociceptive neurons in the intralaminar nucleus of the thalamus

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We previously reported that electrical stimulation of the cervical vagus nerve (CVN) activated an ascending antinociceptive system to the nucleus ventralis posteromedialis of the cat thalamus. In the present study, we investigated the effect of CVN stimulation on the response of nociceptive neurons recorded from the nucleus centralis lateralis (CL) of the thalamic intralaminar nuclei (IL) to tooth pulp (TP) stimulation and to mesencephalic reticular formation (MRF) stimulation. A total of 22 CL neurons responding both to MRF stimulation as well as to TP stimulation, were obtained using cats anesthetized with urethane and chloralose. CVN stimulation inhibited the response to TP stimulation, but not to MRF stimulation (9 of 22 neurons). However, CVN stimulation had no effect on the response to electrical stimulation of the MRF. These results suggest that vagal afferents can activate the descending antinociceptive system that acts on the lower brainstem, and that there is no ascending pain suppression system acting on the CL that is controlled by vagal afferent input. (J Osaka Dent Univ 2005 ; 39 : 1-9.)
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