老人性痴呆の発症機構とその保護・治療薬開発の可能性

概要

論文の詳細を見る
Local ischemia in the specific region of brain has been regarded as one of major causes for senile dementia. Transient increase in intracellular Ca2+ concentration ([Ca2+]i) of neuronal cells in hippocampal CA1 region has been found to result in so called delayed neuronal cell death. Increase in [Ca2+]i was also induced by administration of parathyroid hormone (PTH), an important hormone for plasma Ca2+ level. The hormone in a concentration as low as 10 pM caused neuronal cell death in hippocampal organotypic culture within one week. Since plasma PTH level tends to increase in elderly, PTH should be paid attention to be one of the risk factors for senile dementia. Protection of neuronal cells against the Ca2+ overloading may be one of the important treatment for the rescuing the neurons from the death due to senescence.
日本質量分析学会の論文
1999-06-01