Isoflavones Found in Korean Soybean Paste as 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors
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概要
- 論文の詳細を見る
3-Hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase is the rate-limiting enzyme in the biosynthesis of cholesterol in mammals. Some microbial metabolites have been found to be HMG-CoA reductase inhibitors. Korean soybean paste is a unique food fermented by many microorganisms. The enzymatic method using the catalytic domain of Syrian hamster HMG-CoA reductase was employed for the screening of HMG-CoA reductase inhibitors. Soybean paste extract was fractionated by vacuum liquid chromatography. Fractions showing relatively high HMG-CoA reductase inhibition were further purified through Sephadex LH-20 column chromatography and C18 preparative HPLC, and the inhibitory compounds were identified as genistein, daidzein, and glycitein.
- 社団法人 日本農芸化学会の論文
- 2004-05-23
著者
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MOON Tae
Department of Medicine, University of Alberta
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LEE Soon
Department of Physiology and Molecular Medicine, Medical College of Ohio
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Choi Seung
Department of Medicine, Cardiac and Vascular Center, Cardiovascular Imaging Center, Samsung Medical
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Sung Jang
Department Of Food Science And Technology School Of Agricultural Biotechnology And Center For Agricu
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PARK Kwan
Department of Neurosurgery,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,R
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Sung Jong
Central Research Institute Il Hwa Co. Ltd
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Moon Tae
Department Of Agricultural Biotechnology And Center For Agricultural Biomaterials Seoul National Uni
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Moon Tae
Department Of Food Science And Technology School Of Agricultural Biotechnology And Center For Agricu
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Park Kwan
Department Of Food Science And Technology School Of Agricultural Biotechnology And Center For Agricu
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Park Kwan
Department Of Food Science & Technology Seoul National University
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Park K
Division Of Applied Life Science (bk21 Program) Department Of Agricultural Chemistry Institute Of Ag
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Lee Soon
Department Of Chemistry College Of Natural Science Sungkyunkwan University
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Choi Seung
Department Of Applied Chemistry Konkuk University
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Park Kwan
Department Of Biology Yonsei University:(present)department Of Botany North Carolina State Universit
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Park Kwan
Department Of Anesthesiology And Pain Medicine Ajou University School Of Medicine
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