Isoflavones Inhibit 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase in Vitro
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概要
- 論文の詳細を見る
Isoflavones identified as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in soybean paste were assayed using the catalytic portion of Syrian hamster HMG-CoA reductase, and the kinetic values were measured using HMG-CoA and NADPH. The inhibition of HMG-CoA reductase by these inhibitors was competitive with HMG-CoA and noncompetitive with NADPH. Ki values for genistein, daidzein, and glycitein were 27.7, 49.5, and 94.7 μM, respectively.
- 2004-02-23
著者
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MOON Tae
Department of Medicine, University of Alberta
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Sung Jang
Department Of Food Science And Technology School Of Agricultural Biotechnology And Center For Agricu
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PARK Kwan
Department of Neurosurgery,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,R
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Sung Jong
Central Research Institute Il Hwa Co. Ltd
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Moon Tae
Department Of Agricultural Biotechnology And Center For Agricultural Biomaterials Seoul National Uni
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Moon Tae
Department Of Food Science And Technology School Of Agricultural Biotechnology And Center For Agricu
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Park Kwan
Department Of Food Science And Technology School Of Agricultural Biotechnology And Center For Agricu
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Park Kwan
Department Of Food Science & Technology Seoul National University
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Park K
Division Of Applied Life Science (bk21 Program) Department Of Agricultural Chemistry Institute Of Ag
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LEE Sung-Joon
Stanford School of Medicine, Palo Alto Medical Research Foundation
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Lee Soon
Department Of Chemistry College Of Natural Science Sungkyunkwan University
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Park Kwan
Department Of Biology Yonsei University:(present)department Of Botany North Carolina State Universit
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Park Kwan
Department Of Anesthesiology And Pain Medicine Ajou University School Of Medicine
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