環境化学物質の内分泌撹乱作用, そして実験の撹乱
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概要
- 論文の詳細を見る
- 2001-08-31
著者
-
下東 康幸
九州大学大学院理学研究院
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Shimohigashi Yasuyuki
Laboratory Of Structure-function Biochemistry Department Of Molecular Chemistry Graduate School Of S
関連論文
- Splicing Variants of pdf Gene in the Honeybee Apis mellifera
- Gene Expression of Circadian Neuropeptide PDF in Honeybee
- Design and Synthesis of α-Helix Peptide Bonding to Prion Protein N-terminal Octarepeat Domain
- Immunological Evidences of Circadian Neuropeptide PDF Isoform Present at the Lamina Outer Cells and Varicose Network in the Optic Lobes of the Cricket Gryllus bimaculatus
- Identification of Novel Isofoms of the Circadian Neuropeptide PDF in the Silk Moth Bombyx mori and their Expression in Brain
- Triplicate Alternative Splicings that Produce Multiple Variants of the PERIOD Protein in the Silk Moth Bombyx mori by Deletion/Insertion of Peptides
- cDNA Cloning and mRNA Expression of the Circadian Neuropeptide PDF in the Silk Moth Bombyx mori
- Structural Analysis and Identification of Novel Isoforms of the Circadian Clock Gene period in the Silk Moth Bombyx mori(Neurobiology)
- Primary Structure Analyses of Circadian Neuropeptide PDF and Its Precursors in Insect Cicadae and Flies
- Two Distinctly Different Isoforms With/Without Pentapeptide Fragment in the Silk Moth Clock Protein PERIOD
- A CIRCADIAN NEUROPEPTIDE, PDF, IN THE LAST-SUMMER CICADA MEIMUNA OPALIFERA(Physiology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- cDNA Cloning and Nuclear Localization of the Circadian Neuropeptide Designated as Pigment-Dispersing Factor PDF in the Cricket Gryllus bimaculatus
- Design and Preparation of Universal Anti-PERIOD Antibodies and their Immunoresponses
- Structure and Function of Nuclear Localization Signal Peptide Present in Circadian Rhythm Hormone Peptide Precursor
- 平成15年度九州大学学生生活・修学相談セミナー : 「各学部の修学支援の取り組みと課題」
- Synthesis of Endomorphin-2Analogues Containing Piperidinecarboxylic Acid (Pip) and 2-Azetidinecarboxylic Acid (Aze)
- Synthesis and Biological Activity of Endomorphin-2 Analogues Containing Pro Mimics
- Synthesis and Binding Activities of Endomorphin Analogs Containing 1-Aminocyclopropane-1-carboxylic Acid
- Synthesis and Receptor-Binding Activity of Morphiceptin Analogs Containing α, α-Disubstituted Glycine in the Position 2
- Synthesis and Receptor-binding Activity of Endomorphin Analogs Containing α, α-Disubstituted Glycine
- Molecular Cloning and In Situ Hybridization of Circadian Neuropeptide PDF Receptor in the Fruit Fly Drosophila melanogaster
- Structure-Activity Studies of FMRFamide-Related Peptides in Activating the Specific Receptor Present in the Housefly Musca domestica
- 昆虫の時計細胞がペプチドホルモンをつくる : 概日リズムを伝達するペースメーカーホルモン
- 昆虫の概日リズムペースメーカーペプチドホルモンPDF
- cDNA Cloning of PDF Peptide Precursors in House Fly and Last Summer Cicada
- Ligand-inducing Conformation Changes in the Estrogen Receptor C-Terminal Tail Moiety and Their Sensing by Polyclonal Antibodies
- Preparation of the Antibody Which Discriminates the Conformations of Ligand-bound and Ligand-free Estrogen Receptors : Applications to the Quantitative Analysis of Ligand Bindings
- Aggregation Feature of Fluorine-Substituted Benzene Rings and Intermodular C-H…F Interaction: Crystal Structure Analyses of Mono- and Trifluoro-L-phenylalanines
- Structural Requirement of Housefly FMRFamide Peptides in Its Receptor Activation
- FMRFamide-Related Peptides in the Nervous System of the Housefly Musca domestica : cDNA Cloning and Actions on Clam Heart Contraction
- INTERACTION OF HIGHLY BIOACTIVE GRAMICIDIN S ANALOG LACKING HYDROPHILIC AMINO ACID RESIDUES WITH BIOMEMBRANES
- Double-labelled in situ Hybridization Reveals the Lack of Co-localization of mRNAs for the Circadian Neuropeptide PDF and FMRFamide in Brains of the Flies Musca domestica and Drosophila melanogaster
- IMMUNOCYTO- AND HISTOCHEMICAL ANALYSIS ON THE CIRCADIAN NEUROPEPTIDE PDF IN GRYLLUS BIMACULATUS(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Immunocytochemical Identification the Circadian Neuromodulator PDF in the Housefly Musca domestica : Formation of Mature Peptide
- Immunocytochemical Studies on the Circadian Neuropeptide PDF in the Cricket Gryllus bimaculatus
- Structural Characteristics of Drosophila Estrogen-related Receptor Ligand Binding Domain to Capture the Peptide and Non-peptide Ligands
- LOCALIZATION PROFILES OF ORCADIAN NEUROPEPTIDE PDF IN THE BRAIN OF FLIES, MUSCA DOMESTICA(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- cDNA Cloning and in situ Hybridization of Sulfated Peptide, Sulfakinin, on Housefly Musca domestica
- Localization Profiles of Circadian Neuropeptide PDF in Brain of the Cricket Gryllus Bimaculatus
- LOCALIZATION PROFILES OF CIRCADIAN NEUROPEPTIDE PDF IN THE BRAIN OF CRICKET, GRYLLUS BIMACULATUS(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Molecular Cogs of the Insect Circadian Clock
- Functional Analysis of F-Domain Peptides Important for the Basal Constitutive Activity of Human Nuclear Receptor
- α-Helix Peptides for Bio-Panning in the Phage Display Method to Obtain the Antibodies Specific for Conformation Change in Nuclear Receptors
- Highly Sensitive Monoclonal Antibodies to Distinguish Conformational Changes Induced by Endocrine Disrupting Chemicals in the Estrogen Receptor
- Specific Affinity Labeling of Cys60 in the δ Opioid Receptor by Npys-containing Dynorphin A Analog
- Differential Receptor Binding Characteristics of the Phenylalanine Residues at Positions 3-4 of Endomorphin-2
- The Role of Deltorphin II Phenylalanine Residue in Binding to the δ Opioid Receptor
- Exploration of the Role of Phenylalanine in the Thrombin Receptor Tethered-Ligand Peptide by Substitution with a Series of Trifluorophenylalanines
- The Mode of Molecular Interation of Phe-3 of Deltorphin II and Endomorphin 2 in Opioid Receptor Binding
- Receptor Interaction Mode of the Phe-phenyl Group of Opioid Peptides
- Exploration of Universal Cysteines in the Bining Sites of Therr Opioid Receptor Subtypes by Disulfide-Bonding Affinty Labeling with Chemically Activated Thiol-Containing Dynorphin A Analogs
- Placenta Expressing the Greatest Quantity of Bisphenol A Receptor ERRγ among the Human Reproductive Tissues : Predominant Expression of Type-1 ERRγ Isoform
- 胎盤・胎児脳に高発現の自発活性化型核内受容体ERRγに対する環境ホルモン・ビスフェノールAの結合とリスク
- Direct Measure of Fluorescence Intensity for Efficient Receptor-binding Assay : Conjugates of Ethinylcarboxyestradiol and 5(and 6)-Carboxyfluorescein via α,ω-Diaminoalkanes as a Tracer for Estrogen Receptor
- The Conformation Change-Sensing Antibodies for Retinoid-Related Orphan Receptor Family
- Differential Receptor Recognition by Dmt-Containing Enkephalin Dimers Cross-Linked by Phenylenediamines
- The Molecular Mechanism of ORL1 Nociceptin Receptor in Activation : Residual Essentials in the Sixth Transmembrane Domain
- Structural Analysis of Excitatory Neuropeptides TEP-1 and TEP-2 Isolated from the Prosobranch Gastopod Thais clavigera
- Optimization of the N-Terminal Group of Ac-RYYRIK-NH_2 as ORL1 Receptor Antagonist
- The Effect of Amino Acid Substitution on Oligomerization of Octapeptide Repeat Structure in Prion Protein
- Structural Profiles for Coacervation of Elastin-derived Polypeptides
- The Output Mechanism of Circadian Pacemaker Neuropeptide PDF in the Regulation of Bimodal Locomotor Distribution
- Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERRγ
- Immunological Confirmation of Circadian-Related Neuropeptide PDF-Isoform Peptide in the Cricket Gryllus bimaculatus
- Development of μ-Receptor Selective Opioid Mimetics Derived from Endomorphin Sequences
- Characterization and Application of Monoclonal Antibody Specific for Ser(P)-Gln Phosphorylation Motif
- Monoclonal Antibody Sensing Assay for Conformation Change Induced by Metal Binding to Prion Protein N-Terminal Octarepeat Domain
- Isobutyryl-RYYRIK-NH_2, A Highly Potent Nociceptin Antagonist
- Conformation Change-sensing Assay Using Monoclonal Antibody for N-terminal Octapeptide Repreat Region of Prion Protein
- Structural Characterisitics of the N-Terminal Octapeptide Repeat Region of Prion Protein
- Structural Requirements of the N-terminal Octapeptide Repeat of Prion Protein
- Structural Requirement of the Acyl Group of Ac-RYYRIK-NH_2, an Antagonist of Algesic Neuropeptide Nociceptin
- Structure-Activity Studies on the Nociceptin Peptidic Antagonist Ac-RYYRIK-NH_2
- Multiple Post-Transcriptional Regulations in Circadian Pacemaker Neuropeptide pdf Gene
- Roles of Each Component of μ-Opioid Ligands Containing Dmt-Pyrazinones
- Synthesis and Bioactivity of Novel Type Pyrazinone Ring-Containing μ-Opioid Ligands
- Generation of a Selective Agonist for Mu-Opioid Receptors by the Dimerization of 2', 6'-Dimethyl-L-Tyrosine through Pyrazinone
- The Structure-Activity Relationship of Dmt-NH-X
- Synthesis of New Pyrazinone Ring-Containing Opioid Mimetics and Studies on Their Structure-Activity Relationship
- Stereoselective Synthesis of Unique L-Tyrosine Analogs : Development of Novel μ-Opioid Receptor Ligands
- Synthesis of Opioid Mimetics Containing a Pyrazinone Ring and Their Activities
- Synthesis of Pure Antagonist of ORL1 Nociceptin Receptor
- Residual Roles of Hydrophobic Amino Acids in the Fifth Transmembrane Domain of ORL1 Receptor in Its Activation
- Enkephalin Dimers Cross-Linked by Diaminobenzene for Homodimeric Opioid Receptors Expressed in COS-7 Cells
- Continuous Activation of the δ-Opioid Receptor by Affinity Labeling
- Synthesis of Endomorphin-2 Analogues, Studies on Their Activities for Opioid Receptors, and Three Dimensional Structure
- Lysine-49-Phospholipases A_2 from Trimeresurus flavoviridis Venom Are Membrane-Acting Enzymes
- BIOLOGICAL EVALUATION OF N-TERMINAL PENTA- AND OCTAPEPTIDES OF NEUROPEPTIDS γ, A HIGHLY POTENT TACHYKININ PEPTIDE
- Characteraization of Superstable Variant Peptide of Human p53 Tetramerization Domain
- Structural Characterization of Phe Residues in the p53 Tetramerization Domain
- Destabilization of Tumor Suppressor Protein p53 Tetramer by Oxidation of Met340
- Characteristic Intra- and Intermolecular Interactions of Dipeptide-Chymotrypsin Complex as Specific Structural Essentials for Enzyme Inhibition
- Receptor Binding Site for the Phe-2-Phenyl Group of Thrombin Receptor-Tethered Ligand Peptide : Analyses by Ala/Tyr Mutant Receptors
- Identification of Receptor Binding Site of Nociceptin-14-15, the Residues for High Receptor Potentiation
- Synergistic Potentiation of Nociceptin by Simultaneous Incorporation of Basic Amino Acids at the Consecutive Positions 14-15
- Activity Enhancement by Introduction of Two Different Halogen Atoms into Phe-2-phenyl Group of Thrombin Receptor Tethered-Ligand Analogs
- Edge-to Face CH/π Interaction between Ligand Phe-Phenyl and Receptor Aromatic Group in the Thrombin Receptor Activation
- Highly Potent Peptide Ligands for Thrombin Receptor
- 環境化学物質の内分泌撹乱作用, そして実験の撹乱
- 閑話閑談