Structural Requirement of the Acyl Group of Ac-RYYRIK-NH_2, an Antagonist of Algesic Neuropeptide Nociceptin
スポンサーリンク
概要
- 論文の詳細を見る
- 2004-03-01
著者
-
Takami N
Department Of Dental Materials Science And Technology Iwate Medical University School Of Dentistry
-
SHIMOHIGASHI Yasuyuki
Laboratory of Structure-Function Biochemistry, Department of Chemistry, Kyushu University
-
HONDA Takeshi
Laboratory of Structure-Function Biochemistry, Kyushu University
-
Honda Takeshi
Laboratory Of Structure-function Biochemistry Kyushu University
-
ISOZAKI Kaname
Laboratory of Structure-Function Biochemistry, Faculty and Graduate School of Science, Kyushu Univer
-
Shimohigashi Yasuyuki
九州大学 理学研究院化学部門構造機能生化学
-
Isozaki Kaname
Laboratory Of Structure-function Biochemistry Kyushu University
-
Isozaki K
Laboratory Of Structure-function Biochemistry Kyushu University
-
Shimohigashi Yasuyuki
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
-
NOSE Takeru
Laboratory of Biochemistry, Department of Chemistry, Faculty of Science, Kyushu University
-
Honda T
Osaka Univ. Osaka Jpn
-
Takeru Nose
Department Of Chemistry Faculty Of Sciences Kyushu University
-
Honda Takeshi
Laboratory Of Structure-function Biochemistry Department Of Chemistry Faculty And Graduate School Of
-
Okada Kazushi
Laboratory Of Structure-function Biochemistry Department Of Chemistry Faculty And Graduate School Of
-
COSTA Tommaso
Laboratorio di Farmacologia Istituto Superiore di Sanita
-
Nose Takeru
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
-
KAWANO Michiaki
Laboratory of Structure-Function Biochemistry, Department of Chemistry, Faculty and Graduate School
-
Shimohigashi Yasuyuki
Laboratory Of Structure-function Biochemistry Department Of Molecular Chemistry Graduate School Of S
-
Costa Tommaso
Laboratorio Di Farmacologia
-
Kawahara Megumi
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
-
Isozaki Kaname
Laboratory Of Structure-function Biochemistry Faculty And Graduate School Of Science Kyushu Universi
-
Okada Kazushi
Laboratory Of Structure-function Biochemistry Kyushu University
-
Kawano Michiaki
Laboratory Of Structure-function Biochemistry Department Of Chemistry Faculty And Graduate School Of
-
Kawahara M
Laboratory Of Structure-function Biochemistry Department Of Chemistry Faculty And Graduate School Of
-
Honda Takeshi
Laboratory For Culture Collections Research Institute For Microbial Diseases Osaka University
-
Isozaki Kaname
Laboratory Of Structure-function Biochemistry Department Of Chemistry Faculty And Graduate School Of Sciences
-
Costa Tommaso
Laboratori di Farmacologia, Istituto Spuperiore di Santiá
関連論文
- Splicing Variants of pdf Gene in the Honeybee Apis mellifera
- Design and Synthesis of α-Helix Peptide Bonding to Prion Protein N-terminal Octarepeat Domain
- Immunological Evidences of Circadian Neuropeptide PDF Isoform Present at the Lamina Outer Cells and Varicose Network in the Optic Lobes of the Cricket Gryllus bimaculatus
- Identification of Novel Isofoms of the Circadian Neuropeptide PDF in the Silk Moth Bombyx mori and their Expression in Brain
- cDNA Cloning and mRNA Expression of the Circadian Neuropeptide PDF in the Silk Moth Bombyx mori
- Structural Analysis and Identification of Novel Isoforms of the Circadian Clock Gene period in the Silk Moth Bombyx mori(Neurobiology)
- cDNA Cloning and Nuclear Localization of the Circadian Neuropeptide Designated as Pigment-Dispersing Factor PDF in the Cricket Gryllus bimaculatus
- Design and Preparation of Universal Anti-PERIOD Antibodies and their Immunoresponses
- Synthesis and Binding Activities of Endomorphin Analogs Containing 1-Aminocyclopropane-1-carboxylic Acid
- Synthesis and Receptor-Binding Activity of Morphiceptin Analogs Containing α, α-Disubstituted Glycine in the Position 2
- Chymotrypsin Inhibition Induced by Side Chain-Side Chain Intramolecular CH/π Interaction in D-Thr-L-Phe Benzylamide
- πHydrogen Bond Between Dipeptide Side Chains as a Structural Essential for Chymotrypsin Inhibition
- Ligand-inducing Conformation Changes in the Estrogen Receptor C-Terminal Tail Moiety and Their Sensing by Polyclonal Antibodies
- Structural Characteristics of Drosophila Estrogen-related Receptor Ligand Binding Domain to Capture the Peptide and Non-peptide Ligands
- LOCALIZATION PROFILES OF ORCADIAN NEUROPEPTIDE PDF IN THE BRAIN OF FLIES, MUSCA DOMESTICA(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Localization Profiles of Circadian Neuropeptide PDF in Brain of the Cricket Gryllus Bimaculatus
- LOCALIZATION PROFILES OF CIRCADIAN NEUROPEPTIDE PDF IN THE BRAIN OF CRICKET, GRYLLUS BIMACULATUS(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- α-Helix Peptides for Bio-Panning in the Phage Display Method to Obtain the Antibodies Specific for Conformation Change in Nuclear Receptors
- Highly Sensitive Monoclonal Antibodies to Distinguish Conformational Changes Induced by Endocrine Disrupting Chemicals in the Estrogen Receptor
- Specific Affinity Labeling of Cys60 in the δ Opioid Receptor by Npys-containing Dynorphin A Analog
- Differential Receptor Binding Characteristics of the Phenylalanine Residues at Positions 3-4 of Endomorphin-2
- The Role of Deltorphin II Phenylalanine Residue in Binding to the δ Opioid Receptor
- Exploration of the Role of Phenylalanine in the Thrombin Receptor Tethered-Ligand Peptide by Substitution with a Series of Trifluorophenylalanines
- The Mode of Molecular Interation of Phe-3 of Deltorphin II and Endomorphin 2 in Opioid Receptor Binding
- Receptor Interaction Mode of the Phe-phenyl Group of Opioid Peptides
- Exploration of Universal Cysteines in the Bining Sites of Therr Opioid Receptor Subtypes by Disulfide-Bonding Affinty Labeling with Chemically Activated Thiol-Containing Dynorphin A Analogs
- Affinity Labeling of Opioid Receptor Subtypes by Activated Thiol-containig Dynorphin A Analogs
- Different Roles of Two Consecutive Leucine Residues in a Receptor-Tethered Ligand Peptide (SFLLRNP) in Thrombin Receptor Activation
- The Conformation Change-Sensing Antibodies for Retinoid-Related Orphan Receptor Family
- Differential Receptor Recognition by Dmt-Containing Enkephalin Dimers Cross-Linked by Phenylenediamines
- The Molecular Mechanism of ORL1 Nociceptin Receptor in Activation : Residual Essentials in the Sixth Transmembrane Domain
- Structural Analysis of Excitatory Neuropeptides TEP-1 and TEP-2 Isolated from the Prosobranch Gastopod Thais clavigera
- Optimization of the N-Terminal Group of Ac-RYYRIK-NH_2 as ORL1 Receptor Antagonist
- Structural Profiles for Coacervation of Elastin-derived Polypeptides
- Reversible Affinity Labeling of Opioid Receptors via Disulfide Bonding: Discriminative Labeling of μ and δ Subtypes by Chemically Activated Thiol-Containing Enkephalin Analogs
- Isobutyryl-RYYRIK-NH_2, A Highly Potent Nociceptin Antagonist
- Conformation Change-sensing Assay Using Monoclonal Antibody for N-terminal Octapeptide Repreat Region of Prion Protein
- Structural Characterisitics of the N-Terminal Octapeptide Repeat Region of Prion Protein
- Structural Requirements of the N-terminal Octapeptide Repeat of Prion Protein
- Structural Requirement of the Acyl Group of Ac-RYYRIK-NH_2, an Antagonist of Algesic Neuropeptide Nociceptin
- Structure-Activity Studies on the Nociceptin Peptidic Antagonist Ac-RYYRIK-NH_2
- New Index for the Stability of a Type I Collagen Affected by Hydrophobic Environment
- Synthesis of Pure Antagonist of ORL1 Nociceptin Receptor
- Residual Roles of Hydrophobic Amino Acids in the Fifth Transmembrane Domain of ORL1 Receptor in Its Activation
- Enkephalin Dimers Cross-Linked by Diaminobenzene for Homodimeric Opioid Receptors Expressed in COS-7 Cells
- Continuous Activation of the δ-Opioid Receptor by Affinity Labeling
- Elastin-derived Peptides : Structure, Functions and Mechanisms
- RECEPTOR-MEDIATED BINDING OF ELASTIN-DERIVED HEXAPEPTIDE TO MACROPHAGES INDUCED A GALACTOSUGAR-SENSITIVE CHEMOTAXIS
- Comparison of Chemotactic Activity of Macrophages Induced by Permutations of Elastin-derived Hexapeptide VGVAPG and Pentapeptide VGVPG
- Chemotactic Activation of Macrophages by Elastin Hexapeptide Sequences and Its Signaling Mechanism
- Elastin Peptide-Induced Macrophage Chemotaxis and Its Signal Transduction Pathway
- Involvement of Intracellular Cyclic GMP and Cyclic GMP-Dependent Protein Kinase in α-Elastin-Induced Macrophage Chemotaxis
- Structural Requirement of Nociceptive Peptide Nociceptin : Structural Importance of C-Terminal Fragment for Receptor Recognition
- Structure-Activity Relationships of a Naturally Occurring Nociceptive Peptide, Nociceptin
- Characteristic Intra- and Intermolecular Interactions of Dipeptide-Chymotrypsin Complex as Specific Structural Essentials for Enzyme Inhibition
- Receptor Binding Site for the Phe-2-Phenyl Group of Thrombin Receptor-Tethered Ligand Peptide : Analyses by Ala/Tyr Mutant Receptors
- Identification of Receptor Binding Site of Nociceptin-14-15, the Residues for High Receptor Potentiation
- Synergistic Potentiation of Nociceptin by Simultaneous Incorporation of Basic Amino Acids at the Consecutive Positions 14-15
- Activity Enhancement by Introduction of Two Different Halogen Atoms into Phe-2-phenyl Group of Thrombin Receptor Tethered-Ligand Analogs
- Edge-to Face CH/π Interaction between Ligand Phe-Phenyl and Receptor Aromatic Group in the Thrombin Receptor Activation
- Highly Potent Peptide Ligands for Thrombin Receptor
- Chemical Syntheses of Phenylalanine Derivatives Containing Halogenated Benzene Ring as Structural Explorers for Elucidation of Molecular Mechanisms of Receptor Interacions
- Desieg and Synthesis of para-Fluorophenylalanine Amide Derivatives as Thrombin Receptor Antagonists
- Structural Essentials for Agonist-Antagonist Actions of Thrombin Receptor Tethered-Ligand
- Importance of Ligand Phe-phenyl Group for Activation of Thrombin Receptor
- Interaction Mode of the Phe-Phenyl Group of Thrombin Receptor-Tethered Ligand SFLLRNP in Receptor Activation
- The Role of Arginine in Thrombin Receptor Tethered-Ligand Peptide in Intramolecular Receptor Binding and Self-Activation
- Effects of Substitution of Hydrophobic Amino Acids by Tryptophan on Receptor Binding and Biological Activity of Neuropeptide Nociceptin
- Effect of HEMA Adsorption on the Stability of Native and Denatured Type I Tendon Collagen
- The Effects of Alcoholic Compounds on the Stability of Type I Collagen Studied by Differential Scanning Calorimetry
- The Effects of Arg→Trp and Lys→Trp Substitutions for Arg-Lys^ Residues in a Superagonist [Arg-Lys^]-Nociceptin on the ORL1 Receptor Binding and Activation
- Molecular Mechanism of α-Helix Peptide That Inhibits Intermolecular Interaction of Prion Protein N-Terminal Tetrarepeat Domain
- Histidines as Structurally Essential Residue for the Delta Opioid Receptor Activation
- Essential Amino Acid Residues in the ORL1 Receptor Transmembrane Domains for Receptor Activation
- Platelet Aggregation Activity of Thrombin Receptor-Tethered Peptide Ligand Containing Free Thiol or Activated SH Group
- Design and Synthesis of para-Fluorophenylalanine Amide Derivatives Containing N-Terminal Thiol as Thrombin Receptor Antagonist
- Conformation Change of α-Helix Peptide for Sensing of Deactivation of Nuclear Receptor : Immunoassay Using Polyclonal Antibody Specific for the C-Terminal α-Helix 12 of Estrogen-Related Receptor γ(ERRγ)
- Hetero-Oligomer Formation of Peptides Derived from Tetramerization Domain in Tumor Suppressor Protein p53
- Leucine-14 of Nociceptin Is a Structural Element in the CH/π Interaction with the Receptor Aromatic Group
- Structural Requirements in Activation of Opioid Receptor-Like ORL1 Receptor by Nociceptin
- Structure-Activity Relationships of Serine Protease Inhibitors with Structural Element Stacking to the Catalytic Residue His-57
- The Effect of Structural Difference between Dipeptide C-Terminal Benzyl Amides and Esters on Chymotrypsin Inhibition
- Peptide Library-Derived Inhibitors of Lipolytic Enzyme Phospholipase A_2
- Three Dimensional Crystal Structure of Dipeptide-Chymotrypsin Complex Revealed a Novel Inhibitory Interaction
- Contractile Activity of Drosophila FMRFamide-Related Peptides in the Meretrix Lusoria Heart Muscle
- cDNA Cloning of Circadian Rhythm Pacemaker Neuropeptide PDF in Gryllus bimaculatus and Its Nuclear Localization
- Conformation Sensing Assay Using Polyclonal Antibody Specific for the C-terminal α-helix of Glucocorticoid Receptor and Progesterone Receptor
- Bioactive Conformation of a D-Trp-Containing Cardioexcitatory Tripeptide Isolated from the Sea Hare Aplysia
- Effects of the Phe-Phenyl H→F Substitutions in the Sea Hare Aplysia Neuropeptide H-Asn-D-Trp-Phe-NH_2 on the Conformation and Contractile Activity
- The Trp residue of opioid receptor TM5 present at the cell membrane interface is a molecular anchor for full activation
- Exploration of the Binding Site of ORL1 Nociceptin Receptor Antagonist
- Functional Roles of phenylalanine-2 of Thrombin Receptor-Tethered Ligand Peptide in Platelet Activation
- Functional Analysis of a Histidine Residue Essential for Receptor Activation of Delta Opioid Receptor
- Receptor Binding Characteristics of Tritium-Labeled Pure Antagonist Peptide for Hyperalgesic Nociceptin ORL1 Receptor
- Structural Analysis of Delta Opioid Receptor Dimer by Bivalent Deltorphin II Analogs
- Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation
- Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD
- Effects of the Halogenation of Phe-Phenyl Group of Two Consecutive Residues in Endomorphin-2 on the Interaction with the μ-Opioid Receptors
- The Effect of Halogenation of Phe-Phenyl Group of Two Consecutive Phe Residues Present in Neuropeptide Substance P on Its Specific Receptor Interaction
- A Molecular Design of the Thrombin Receptor Antagonist