Reversibility of hepatic fibrosis : from the first report of collagenase in the liver to the possibility of gene therapy for recovery
スポンサーリンク
概要
- 論文の詳細を見る
Since the authors reported the presence of collagenase in the liver as well as its increased activity in the early stage of hepatic fibrosis and its reduced activity in advanced fibrosis in rats induced by chronic CCl4 intoxication, in baboons fed alcohol chronically and in patients with alcoholic fibrosis, other investigators have demonstrated the same tendency of collagenase activity biologically and his-tochemically. Very recently, the authors demonstrated definite gene expression of collagenase during the recovery from experimental hepatic fibrosis using Northern blotting and in situ hybridization. The findings of in situ hybridization not only demonstrated the cells expressing collagenase, but also sug-gested much information on the mechanism of the recovery from fibrosis. Hepatic stellate cells play a key role not only in fibrogenesis but also in fibrolysis. The authors recent observation revealed that collagenase (matrix metalloproteinase-13 (MMP-13)) gene expression appears very early in the pro-cess of recovery from liver fibrosis, and that both stellate cells and hepatocytes express MMP-13. Recovery from liver cirrhosis requires the gene expression of collagenase, increased production of the collagenase enzyme, and activation of the enzyme balanced with the specific inhibitors of collagenase. The understanding of molecular mechanisms of MMP-1 gene expression which is under investigation in our laboratory may provide us a new strategy for the treatment of liver fibrosis including the possibility of gene therapy.
- The Keio Journal of Medicineの論文
- 2001-06-01
著者
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Watanabe Tetsu
Department of Cardiology, Pulmonology, and Nephrology
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Watanabe Tetsu
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Watanabe T
Tokai Univ. School Of Medicine Jpn
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NIIOKA Maki
Department of Community Health, School of Medicine, Tokai University
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OKAZAKI Isao
Department of Community Health, School of Medicine, Tokai University
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Hozawa Shigenari
Department of Public Health, Tokai University School of Medicine
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ARAI Masao
Department of Community Health, School of Medicine, Tokai University, Bouseidai
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Niioka Maki
Department Of Community Health Tokai University School Of Medicine
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Okazaki I
Department Of Community Health Tokai University School Of Medicine
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Okazaki Isao
Department Of Basic Clinical Science And Public Health Tokai University School Of Medicine
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Maruyama Katsuya
Clinical Research Unit Kurihama National Hospital
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Hozawa Shigenari
Department Of Community Health Tokai University School Of Medicine
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Arai Masao
Department Of Applied Physics University Of Tokyo
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Watanabe Tetsu
Department Of Basic Clinical Science And Public Health Tokai University School Of Medicine
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