水晶発振子を用いた分子認識の動的解析

概要

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Quartz Crystal Microbalances (QCM) are known to provide very sensitive mass measuring devices because the resonance frequency decreases upon the increase of a given mass on the QCM electrode in a nanogram level. In this review, we describe that the QCM is useful to detect molecular recognition process<I>in situ</I>. For example, when lipid membranes are immobilized on a QCM plate, we could detect the selective adsorption of odor molecules to the lipid matrix from the freqency changes. When dipeptide crystals were immobilized, enantioselective adsorption of amino acid was observed. When the QCM plate was attached hollizontally onto the glycolipid monolayer at the air-water interface, the selective binding of lecithins onto the glycolipid monolayer was observed. When oligonucleotide was immobilized on a QCM, hybridization of DNA double strands were detected from frequency changes.
社団法人日本油化学会の論文
1994-10-20