2分子膜固定化フィルムを用いた刺激応答性透過制御

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How to immobilize bilayer structures in self-standing film and their signal-receptive permeation control of water-soluble substrates are reviewed. There are various method to immobilize lipid bilayers as a self-standing film : (i) casting and drying aqueous despersion of lipid bilayers on a glass plate, (ii) blending lipids with poly (vinylalcohol) or poly (vinylchloride) in a solution and casting on a plate, (iii) coaking lipids in a porous filter membrane, (iv) building-up Langmuir-Blodgett multilayers of lipids on a porous filter, and (v) forming polyion complexes from polyanion and cationic lipids and casting a film from their chloroform solution. Among these methods, the polyion-complex-type bilayer-immobilized film [method (v)] is the most suitable for permeation measurements in aqueous solution. The films is transparent, water-insoluble and physically strong, in which multibilayer structures are well-oriented and piled up parallel to a film plane. Permeation through the bilayer-immobilized film can be reversibly controlled from various outside effects such as temperature (phase transition of bilayers), electric field, and electrochemical redox reactions in lipid bilayers. When the helical structure of poly (L-glutamate) is employed as a counter polyanion, the polyion-complex lipid film shows the stereo-selective permeation of D-, L-triptophan. The lipid bilayer-intercalated clay film can be also prepared when montmorillonite clay is used as counter anioms.
日本膜学会の論文

著者

岡畑恵雄
東京工業大学生体分子工学科

2分子膜固定化フィルムを用いた刺激応答性透過制御

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