二分子膜被覆水晶発振子を用いた匂い物質や苦味物質のセンシング

概要

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The gustatory and olfactory cells can detect multifarious substances in external environments. Recently, bitter substances and odorants are suggested to be detected by direct adsorption on a lipid bilayer matrix without a specific receptor protein in receptor membranes and to cause a membrane potential and an impulse generation. In this review, we describe that the adsorption of various bitter and odor substances on a lipid bilayer matrix can be easily detected by observing a frequency change of a synthetic multibilayer-coated piezoelectric crystal in an aqueous or a gas phase. The adsorption process was followed by changes of a membrane potential and a membrane resistance of a synthetic bilayer membrane. The bilayer-coated crystal will become a new tool as an odor sensor and to study the biological mechanism of gustatory and olfactory cells.
日本生物物理学会の論文