Non-invasive and Time-Resolved Observation of Tumors Implanted in Living Mice by Using Phase-Contrast X-ray Computed Tomography

概要

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To achieve in vivo observation of drug effect on tumors implanted in living mice, we have developed a novel method of non-invasive and time-resolved observations by using phase-contrast X-ray computed tomography (CT). For observations, we used a large-area imaging system fitted with a two-crystal X-ray interferometer and a newly developed sample manipulator. A series of images of tumors with or without antitumor drug (paclitaxel) dosage once a day for four days was successfully obtained. Image analysis clearly showed that a low-density region corresponded to necrosis near the center of both tumors spreading gradually. In addition, the density distribution of necrosis in the dosed tumor was lower than that of necrosis in the tumor without dosage. These results indicate that this imaging method has practical applications for non-invasive and time-resolved observations of drug effects on living mice.
Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
2006-03-15