Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules
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概要
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Thermal plasmas and lasers are used in medicine to cut and ablate tissues and for coagulation. Non-equilibrium atmospheric pressure plasma (NEAPP) is a recently developed, non-thermal technique with possible biomedical applications. Although NEAPP reportedly generates reactive oxygen/nitrogen species, electrons, positive ions, and ultraviolet radiation, little research has been done into the use of this technique for conventional free radical biology. Recently, we developed a NEAPP device with high electron density. Electron spin resonance spin-trapping revealed •OH as a major product. To obtain evidence of NEAPP-induced oxidative modifications in biomolecules and standardize them, we evaluated lipid peroxidation and DNA modifications in various in vitro and ex vivo experiments. Conjugated dienes increased after exposure to linoleic and α-linolenic acids. An increase in 2-thiobarbituric acid-reactive substances was also observed after exposure to phosphatidylcholine, liposomes or liver homogenate. Direct exposure to rat liver in saline produced immunohistochemical evidence of 4-hydroxy-2-nonenal- and acrolein-modified proteins. Exposure to plasmid DNA induced dose-dependent single/double strand breaks and increased the amounts of 8-hydroxy-2-deoxyguanosine and cyclobutane pyrimidine dimers. These results indicate that oxidative biomolecular damage by NEAPP is dose-dependent and thus can be controlled in a site-specific manner. Simultaneous oxidative and UV-specific DNA damage may be useful in cancer treatment.
- 日本酸化ストレス学会 JCBN事務局の論文
著者
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Nakamura Kae
Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Kikkawa Fumitaka
Department Of Gynecology And Obstetrics Nagoya University Graduate School Of Medicine
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Uchida Koji
Laboratory Of Food And Biodynam Ics Department Of Applied Biological Sciences Nagoya University
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Toyokuni Shinya
Department Of Pathology And Biological Responses Graduate School Of Medicine Nagoya University
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Wang Yue
Department Of Applied Chemistry Beijing Institute Of Petrochemical Technology
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Okazaki Yasumasa
Department Of Pathology And Biological Responses Nagoya University Graduate School Of Medicine
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Kajiyama Hiroaki
Department Of Endoscopy Aichi Cancer Center Hospital
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KAJIYAMA Hiroaki
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine
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Hori Masaru
Plasma Nano-technology Research Center, Nagoya University, Nagoya 464-8603, Japan
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KANO Hiroyuki
NU Eco Engineering Co., Ltd.
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Tanaka Hiromasa
Plasma Nanotechnology Research Center, Nagoya University
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Wang Yue
Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine
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Mizuno Masaaki
Center for Advanced Medicine and Clinical Research, Nagoya University Hospital
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Hori Masaru
Plasma Nanotechnology Research Center, Nagoya University
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