Differential Expression of Plasma Proteins in Cyclosporine A-Induced Rat Acute Nephrotoxicity
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概要
- 論文の詳細を見る
Cyclosporine A (CsA) is a effective and widely used immunosuppressive agent. Nevertheless, its intense nephrotoxicity restricts clinical application. In this study, wistar rats were randomly divided into a control group, a low-dose group and a high-dose group. The rats in the low-dose group and those in the high-dose group were given CsA at a daily dose of 5 mg per kg and 100 mg per kg by gavage for 7 d respectively, while the control group was given distilled water of equal volume. The extent of renal impairment was evaluated by renal function assay, and urease and pathological observation. The results showed that the rats in the low-dose group did not suffer remarkable renal impairment, while the rats in the high-dose group did. Two-dimensional gel electrophoresis (2DE) was utilized to resolve the plasma protein profile. Six spots showing stable and significantly different expression were identified by MALDI-TOF-MS and ESI-TOF-MS/MS respectively, the two induced proteins were identified respectively as α-1-acid glycoprotein (AAG) and clusterin (CLUS), and the one inhibited was haptoglobin (Hp).
- 社団法人 日本農芸化学会の論文
- 2009-03-23
著者
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Wang Yue
Department Of Computer Science University Of Tokyo
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Li Quan
Department Of Diving Medicine Faculty Of Navy Medicine Second Military Medical University
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Xiong Xin
Department Of Pharmacy Peking University Third Hospital
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Wang Yue
Department Of Nephrology Peking University Third Hospital
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Li Quan
Department Of Molecular And Cellular Pharmacology School Of Pharmaceutical Sciences Peking Universit
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Xiong Xin
Dep. Of Pharmacy Peking Univ. Third Hospital
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Zhai Suodi
Department Of Pharmacy Peking University Third Hospital
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Pu Xiaoping
Department Of Molecular And Cellular Pharmacology School Of Pharmaceutical Sciences Peking Universit
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Pu Xiaoping
Department Of Molecular And Cellular Pharmacology School Of Pharmaceutical Science Peking University
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SHU Zhan
Department of Pharmacy, Peking University Third Hospital
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Shu Zhan
Department Of Pharmacy Peking University Third Hospital
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Wang Yue
Department Of Applied Chemistry Beijing Institute Of Petrochemical Technology
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