Risk of Hypercholesterolemia in Patients with Cardiovascular Disease and the Population Attributable Fraction in a 24-year Japanese Cohort Study

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概要

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• Aims: The population-attributable fraction (PAF) is an indicator of the disease burden. In Western countries, the PAF of hypercholesterolemia in cardiovascular disease (CVD) is the highest among that for traditional risk factors; however, data for Asian populations are limited.Methods: A 24-year cohort study was conducted among 9,209 randomly selected patients who were not taking statins. We estimated the hazard ratio (HR) after adjusting for covariates and PAF associated with the serum total cholesterol (TC) levels in relation to CVD mortality.Results: The TC level was found to be positively associated with an increased risk of CVD, coronary heart disease (CHD) and cardiac death (CHD plus heart failure), with an HR of 1.08 (95% confidence interval [CI]: 1.00-1.16), 1.33 (95% CI: 1.14-1.55) and 1.21 (95% CI: 1.08-1.35) for a 1-SD increment in the serum TC level, respectively. Similar positive associations between the TC level and both CHD and cardiac death were observed after classifying the patients by age and sex. Furthermore, the highest serum TC level (≥6.72 mmol/L) was positively associated with CVD death, with an HR of 1.76 (95% CI: 1.25-2.47), as well as both CHD death and cardiac death. In contrast, no significant relationships were observed between the serum TC level and stroke. Meanwhile, the PAF for CVD, CHD, and cardiac deaths due to hypercholesterolemia (serum TC level ≥5.69 mmol/L, defined by the Japan Atherosclerosis Society) was 1.7%, 10.6% and 5.6%, respectively.Conclusions: The estimated PAF of CVD death due to hypercholesterolemia is moderately high, but lower than that for other risk factors, such as hypertension.

• 一般社団法人 日本動脈硬化学会の論文

著者

• Miyamoto Yoshihiro

  Department of Arthelosclerosis and Diabetes Melitus, National Cardiovacular Center Research Institut

• Okuda Nagako

  Department Of Health Science Shiga University Of Medical Science

• Kita Yoshikuni

  Department Of Health Science Shiga University Of Medical Science

• Sugiyama Daisuke

  Department Of Chemistry Faculty Of Science And Engineering Saga University

• Ohkubo Takayoshi

  Department Of Clinical Pharmacology And Therapeutics Tohoku University

• Miyamatsu Naomi

  Department Of Clinical Nursing Faculty Of Medicine Shiga University Of Medical Science

• Okamura Tomonori

  Department Of Cardiology National Cardiovascular Center

• Murakami Yoshitaka

  Department Of Health Science Shgia University Of Medical Science

• Hayakawa Takehito

  Department Of Cancer Control And Statistics Osaka Medical Center For Cancer And Cardiovascular Diseases:for The Hipop-ohp Research Group

• Watanabe Makoto

  Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University

• Higashiyama Aya

  Department of Environmental and Preventive Medicine, Hyogo College of Medicine

• NAKAMURA Yasuyuki

  Department of Agricultural Chemistry, Faculty of Agriculture, Niigata University

• Higashiyama Aya

  Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center

• Hozawa Atsushi

  Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University

• Kadota Aya

  Center for Epidemiologic Research in Asia/Department of Public Health, Shiga University of Medical Science

• Miura Katsuyuki

  Center for Epidemiologic Research in Asia/Department of Public Health, Shiga University of Medical Science

• Okayama Akira

  Research institute for lifestyle-related disease prevention

• Ueshima Hirotsugu

  Center for Epidemiologic Research in Asia/Department of Public Health, Shiga University of Medical Science

• Okuda Nagako

  Department of Health and Nutrition University of Human Arts and Sciences

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