唾液腺悪性腫瘍におけるc-erbB-2発現の免疫組織学的検討

概要

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Expression of c-erbB-2 oncoprotein in salivary gland carcinomas was examined by immunohistochemical study to determine the incidence and significance of this protein. Six of 18 cases (33.3%) of primary salivary gland carcinoma showed positive membrane staining with a monoclonal antibody to the c-erbB-2 oncoprotein on formalin-fixed, paraffin-embedd- ed sections. According to clinical follow-up data, regional lymph node metastasis was observed in 4 of 6 patients with overexpression of c-erbB-2, but the frequency was not statistically significant. There was no clear evidence of an association between the demonstration of c-erbB-2 protein and other prognostic factors such as tumor size, metastasis, recurrence of tumor or overall survival rate.
耳鼻咽喉科臨床学会の論文