スギ花粉症に対する予防的薬物療法の研究:とくに麻黄附子細辛湯について

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The prophylactic and therapeutic effects of Mao-bushi-saishin-to extract capsules were investigated in Japanese cedar pollinosis according to our criteria for efficacy evaluation. The drug was administered to patients who were seen before the beginning of the scattering season (prophylaxis group,57 patients) and the course of onset and severity of symptoms were investigated in an early period of pollen scattering and 2 and 4 weeks after pollen scattering. The drug was also administered to patients who were seen after the beginning of the scattering season (therapy group,71 patients) to investigate its therapeutic effect. In addition, by reviewing the allergy diaries, the relationship between the scattered pollen count and each symptom was investigated. In the prophylaxis group, the efficacy rate (>moderate) was 100% in the early period of scattering,55.1% at week 2 after scattering and 65.2% at week 4. The severity rating was mild or less in 93.2% of the cases in the early period of scattering,44.9% at week 2 after scattering, and 50.0% at week 4. In 16 cases the severity was consistently mild or less throughout the study period. Administration of the drug for 2-4 weeks before scattering resulted in good prophylaxis. In the therapy group, the efficacyr ate (>good) was 44.9% at week 2 of treatment and 48.1% at week 4. The allergy diaries revealedt hat the nasal and ocular symptomsw axed and waned with the status of pollen scattering. Sneezing, nasal discharge and interference with daily life were less severe in the prophylaxis group than in the therapy group which indicates the effectiveness of preseasonal medication. Side effects, viz, ab d ominal distension, flush face, dry mouth and belching, were found in 4 cases but all were slight. The utility rate ( >useful)w as 61.4% in the prophylaxisg roup and 49.3% in the therapy group.
耳鼻咽喉科臨床学会の論文

スギ花粉症に対する予防的薬物療法の研究:とくに麻黄附子細辛湯について

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