シスプラチン封入リポソームを用いた動注化学療法の基礎的研究

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We performed a basic study using the cisplatin-liposome to examine the efficacy of blood vessel embolism by the liposome itself, gradual discharge of the agent from the liposome, and affinity of the liposome to cells. Rats were allotted into 3 groups. Cis p latin and cisplatin-liposome were administered to rats by intravenous injection and intraarterial injection. In group 1, cisplatin alone was administered by intravenous injection, in group 2, cisplatin alone was administered by intraarterial injection, and in group 3, Cisplatin-liposome was administeted by intraarterial injection.<BR>Total platinum concentration in the blood, liver, lungs, kidneys, and the muscle of branching area was measured for 7 days after injection.<BR>Rats bearing tumors were also allotted into 3 groups. Cisplatin and cisplatin liposome were administered to the tumor-bearing rats by intravenous injection and intraarterial injection. In group 1, cisplatin alone was administered by intravenous injection, in group 2, cisplatin alone was administered by intraarterial injection, and in group 3, cisplatin-liposome was administered by intraarterial injection. Tumor size and total platinum concentration in the tumor were measured 8 days after injection, and the pathological changes of the tumor were observed. In all groups, the total platinum concentration in the blood dropped rapidly up to 2 hours after injection.<BR>In all groups, the total platinum concentration in the blood, kidneys and lungs changed similarly. In all groups, the total platinum concentration in kidneys was high.<BR>In the group administered cisplatin-liposome by intraarterial injection, the total platinum concentration in the muscle of the branching area and the liver was higher than that of the other groups.In the tumor-bearing rat group administered cisplatin-liposome by intraarterial injection, the tumor size was smaller than in the other groups, and the total platinum concentration in the tumor was higher than in the other groups. The pathological change of the tumor showed good anticancer efficacy of the cisplatin-liposome. These findings suggest that the cisplatin-lipo some is applicable to selective intraarterial chemotherapy.
耳鼻咽喉科臨床学会の論文

シスプラチン封入リポソームを用いた動注化学療法の基礎的研究

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