鼻アレルギーに対する麻黄附子細辛湯の薬効評価:鼻閉症状の臨床効果について

概要

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Mao-bushi-saishin-to extract capsules (6 caps. /day) were administered orally to 61 perennial nasal allergy patients presenting with nasal obstruction for 4 consecutive weeks to assess the overall efficacy, safety and utility of the drug. In the doctor's evaluation, the overall efficacy rate covering excellent and good responses was 38.3% at week 2 of treatment and 54.7% at week 4 of treatment. The utility rate covering useful and higher ratings was 60.7%.<BR>Nasal symptoms, viz, sneezing attack, nasal discharge, nasal obstruction, dysosmia and interference with daily living were all improved. Nasal obstruction, in particular, disappeared in many cases, thus generating a high improvement rate. Nasal mucosal findings, viz, swelling of inferior turbinal mucosa, watery secretion in nasal cavity, and nasal discharge eosinophil count showed good improvements.<BR>The time course of each nasal symptom i n terms of the average score according to allergy diaries, revealed significant reduction in nasal obstruction, dysosmia and interference with daily life in severity at and after week 2 and sneezing and nasal discharge were significantly alleviated at week 4 as compared with the findings obtained during the baseline period.<BR>As side effects, headache was reported in one case and stomachache in one case. These symptoms were relieved after discontinuation of treatment.
耳鼻咽喉科臨床学会の論文