鼻咽腔に隼じた悪性線維性組織球腫の一例:放射線治療と発症との関連について

概要

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A case of malignant fibrous histiocytoma (MFH) arising in a recurrent juvenile nasopharyngeal angiofibroma (JNA) 20 years after radiation therapy is described. The MFH extended from the nasopharynx into the pterygomaxillary space and infratemporal fossa and infiltrated the skull base. Surgical excisions and radiotherapy caused temporary improvement, but the MFH recurred rapidly. Although administration of MTXVCR/ADM suppressed regrowth of the MFH for 3 months, the patient expired 32 months after initial hospital admission.<BR>A review of the m edical literature revealed six other documented cases of sarcomatous transformation of JNA. In 5 of these cases, the JNAs had been irradiated before sarcomatous change. This high occurrence rate suggests the danger of indiscriminate application of radiation therapy in JNA.
耳鼻咽喉科臨床学会の論文