Identification of a Novel WD Repeat-Containing Gene Predominantly Expressed in Developing and Regenerating Neurons.
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概要
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In the present study, we have identified a novel gene, NDRP (for neuronal differentiation-related protein), which is predominantly expressed in developing and regenerating neurons. The predicted NDRP comprises 1, 019 amino acid residues and has 6 WD repeats in the N-terminal half and multiple potential nuclear localization signals (NLSs) at the C-terminal part. This molecule shows no significant structural similarity with any other molecules in available databases. In situ hybridization and immunohistochemistry revealed the highest expression of NRDP in sensory neurons, for instance, olfactory epithelia and neural layer of retina during embryonic development, as well as in perinatal dorsal root ganglions. The expression of this gene in intact motor neurons such as in the hypoglossal nerve was undetectable but became obvious after axotomy. These results suggest that the product of this gene might be involved in the development of sensory neurons as well as the regeneration of motor neurons.
- 社団法人 日本生化学会の論文
著者
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KIYAMA Hiroshi
Department of Anatomy & Neurobiology, Graduate School of Medicine, Osaka City University
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Taga Tetsuya
Department Of Cell Fate Modulation Institute Of Molecular Embryology And Genetics Kumamoto Universit
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CHEN Shi
Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental Universit
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IKEDA Ken
Fourth Department of Internal Medicine
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Nakashima Kinichi
Department Of Cell Fate Modulation Institute Of Molecular Embryology And Genetics Kumamoto Universit
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Kato Hiroaki
Department Of Agricultural Chemistry Yamagata University
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Kimura Naoki
Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University
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