A Brain Region-Specific Gene Product Lhx6.1 Interacts with Ldb1 through Tandem LIM-Domains.
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概要
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LIM-homeodomain (LHX) transcription factors play critical roles in cell fate determination during development, in particular, in CNS. The transcriptional activity of several LHX proteins is postulated to be regulated by interaction with an LIM-domain binding protein, Ldb1. We have now identified a novel LHX molecule, termed Lhx6.1, that is closely related to a recently reported Lhx6 molecule. The Lhx6.1 transcript is found in several restricted regions in the developing CNS, mostly within the embryonic forebrain. We further show that Lhx6.1 interacts with Ldb1 through tandem LIM-domains, implying transcriptional regulation of Lhx6.1 by Ldb1.
- 社団法人 日本生化学会の論文
著者
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Taga Tetsuya
Department Of Cell Fate Modulation Institute Of Molecular Embryology And Genetics Kumamoto Universit
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Ueno Masaya
Department Of Chemistry Nagaoka University Of Technology
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Nakashima Kinich
Departmet fo Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University
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Kimura Naoki
Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University
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Taga Tetsuya
Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University
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