Successful Surgical Treatment for Pulmonary Crystal-Storing Histiocytosis Following the Onset of Gastric Non-Hodgkin Lymphoma
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概要
- 論文の詳細を見る
Crystal-storing histiocytosis is a rare clinical entity characterized by an increase in the number of abnormal histiocytes accompanied by accumulation of crystallized immunoglobulins. We describe the case of an 80-year-old man who presented with crystal-storing histiocytosis of the lung 13 years after receiving a diagnosis of gastric non-Hodgkin lymphoma (NHL ; clinical stage, Lugano IA). After wedge resection of the left upper lobe, the histological findings showed crystal-storing histiocytosis with CD68<SUP>+</SUP>, some small to medium lymphoid cells with CD79a<SUP>+</SUP> with κ<SUP>+(weekly)</SUP> and λ<SUP>-</SUP>, and some plasma cells with CD138<SUP>+</SUP>, and rearrangement of the immunoglobulin heavy chain. Based on the nonrecurrent gastric NHL, small B-cell population, and failure to detect the same clone by polymerase chain reaction analysis, our case was classified as pulmonary localized crystal-storing histiocytosis without underlying lymphoproliferative or plasma cell disorder. The findings of minor B-cell populations harboring a heavy chain rearrangement with slight light-chain restriction (κ > λ) may be related to the pathogenesis of crystallogenesis and crystal-storing histiocytosis. Moreover, surgical treatment may be an effective therapeutic option for solitary crystal-storing histiocytosis. [<I>J Clin Exp Hematop 53(</I><I>3) : 241-245, 2013</I>]
- 日本リンパ網内系学会の論文
著者
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Shimao Yoshiya
Department Of Pathology Miyazaki Medical College
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Yoshida Shuro
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Ueda Akira
Department Of Applied Mathematics And Physics Faculty Of Engineering Kyoto University
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Ueda Yuji
Department Of Earth And Planetary Science University Of Tokyo
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Himeji Daisuke
Department Of Internal Medicine Miyazaki Prefectural Miyazaki Hospital
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Yamashita Kiyoshi
Department Of Hematology And Oncology Graduate School Of Medicine University Of Tokyo
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Ono Nobuyuki
Department Of Electronics And Control Engineering Nagano National College Of Technology
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Oshima Koichi
Department Of Pathology Fukuoka University School Of Medicine
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Yamaguchi Kenichiro
Department Of Radiology Miyazaki University School Of Medicine
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Kawano Noriaki
Department Of Hematology Harasanshin Hospital
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Oyama Mayumi
Department Of Chest Surgery Shimonoseki City Central Hospital
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Masuyama Hiroyuki
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital
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Masuyama Hiroyuki
Department of Cardiology, Miyazaki Prefectural Hospital, Japan
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Beppu Kiichiro
Department of Surgery, Miyazaki Prefectural Miyazaki Hospital
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Kuriyama Takuro
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital
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Kuriyama Takuro
Department of Internal Medicine, Miyazaki Prefectural Hospital
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Ueda Yuji
Department of Surgery, Miyazaki Prefectural Miyazaki Hospital
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Shimao Yoshiya
Department of Pathlogy, Miyazaki Prefectural Hospital, Japan
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Oyama Mayumi
Department of Surgery, Miyazaki Prefectural Miyazaki Hospital
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BEPPU Kiichiro
Department of Surgery, Miyazaki Prefectural Hospital
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