Cyclophosphamide-induced Cardiotoxicity with a Prolonged Clinical Course Diagnosed on an Endomyocardial Biopsy
スポンサーリンク
概要
- 論文の詳細を見る
A 31-year-old woman with primary mediastinal large B-cell lymphoma refractory to conventional chemotherapy was treated with high-dose chemotherapy containing cyclophosphamide (CY). Subsequently, she was treated with auto peripheral blood stem cell transplantation. Although a complete remission was obtained, heart failure developed two months later. Echocardiography showed an impaired systolic function with pericardial effusion. A biopsy of the endomyocardial region from the left ventricle demonstrated spotty myocardial hemorrhage and myocardial fibrosis with disruption and aggregation of mitochondrial cristae. Based on these findings, CY-induced cardiotoxicity was diagnosed. The patient was treated with conventional therapy for heart failure, which required approximately one year to improve her condition.
- 社団法人 日本内科学会の論文
著者
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Koide Yuji
Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Tsuneto Akira
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome
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Maemura Koji
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome
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Yonekura Tsuyoshi
Department Of Cardiology Nagasaki Citizens Hospital
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Kawano Hiroaki
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
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Satoh Osami
Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Hayashi Tomayoshi
Department Of Cardiovascular Surgery And Pathology Nagasaki University School Of Medicine
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Kusumoto Saburo
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
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Hayashi Tomayoshi
Department of Pathology, Nagasaki University Hospital, Japan
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JO Tatsuro
Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
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TAKENO Masayoshi
Department of Cardiology, Nagasaki Citizens Hospital
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Eguchi Masamichi
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
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Tsuneto Akira
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
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