Valsartan Decreases Type I Collagen Synthesis in Patients With Hypertrophic Cardiomyopathy

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概要

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• Background Fibrosis, as well as myocyte hypertrophy, is the major determinant of prognosis in hypertrophic cardiomyopathy (HCM). Valsartan, an angiotensin II type 1 receptor blocker, may improve myocardial fibrosis in patients with HCM. Methods and Results Twenty-three patients with HCM were randomly divided into 2 groups : 11 patients had valsartan added to conventional treatment (V group) and 12 patients received the conventional therapy (C group). Plasma concentrations of brain natriuretic peptide (BNP), troponin T (TnT), aldosterone (ALDO), procollagen type I (PIP) and procollagen type III aminoterminal peptide (PIIINP) were measured before and 12 months after this study. Left ventricular wall thickness (LVWT) and ejection fraction (LVEF) were measured by echocardiography. PIP was decreased in the V group (123.2±63.1ng/ml to 102.8±37.6, p<0.05), but unchanged in C group (110±40.5ng/ml to 119.9±47.4, p=0.22). ALDO concentration was unchanged in the V group (88.5±26.2pg/ml to 91.2±26.8, p=0.27), and increased in C group (92.6±36.6ng/ml to 116.0±33.3, p<0.05). BNP, PIIINP, and TnT were unchanged by the treatment. There was no significant difference between the 2 groups in either LVWT or LVEF. Conclusion Valsartan suppresses the synthesis of type I collagen in patients with HCM and this was associated with suppression of the increase in ALDO.

• 社団法人日本循環器学会の論文
• 2005-09-20

著者

• Kawano Hiroaki

  Department of Cardiovascular Medicine, Kumamoto University

• SETO Shinji

  Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Bio

• Yano Katsusuke

  Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of B

• Yano Katsusuke

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano Katsusuke

  長崎大学 第3内科

• Kawano Hiroaki

  Division Of Cardiovascular Medicine Department Of Translational Medical Sciences Course Of Medical A

• KOIDE Yuji

  Department of Cardiovascular Medicine, Course of Medical and Dental Science, Graduate School of Biom

• TODA Genji

  Department of Cardiovascular Medicine, Course of Medical and Dental Science, Graduate School of Biom

• Koide Yuji

  Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Nagasaki University

• Seto Shinji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano Katsusuke

  Department Of Cardiology Nagasaki University Hospital

• Nakamizo Reiichirou

  Department of Cardiovascular Medicine, Course of Medical and Dental Science, Graduate School of Biom

• Kawano Hiroaki

  Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ

• Seto Shinji

  Department Of Radiation Epidemiology Atomic Bomb Disease Institute

• Toda Genji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Science Graduate School Of Biomed

• Toda Genji

  Department Of Cardiology Tokyo Metropolitan Geriatric Hospital

• Yano Katsusuke

  Faculty Of Health Management Nagasaki International University

• Seto Shinji

  The Third Department Of Internal Medicine Nagasaki University School Of Medicine

• Nakamizo Reiichiro

  Department Of Cardiovascular Medicine Course Of Medical And Dental Science Graduate School Of Biomed

• Toda Genji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Seto Shinji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Toda Genji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano Katsusuke

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Seto Shinji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• KOIDE Yuji

  Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University

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