Causal Association between Major Histocompatibility Complex and Myocardial Infarction in NZW×BXSB F1 Mice

概要

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The NZW×BXSB F1 male mice that a model for systemic lupus erythematosus(SLE) develop myocardial infarction. To determine whether the gene(s) linked to the major histocompatibility complex(MHC) of NZW mice are involved in myocardial infarction, we developed an H-2-congenic NZW. H-2^d strain and compared the incidence of myocardial infarction in NZW×BXSB F1 (H-2^<z/b>) male mice to that in NZW. H-2^d×BXSB F1 male mice (H-2^<d/b>). H-2^<z/b> heterozygous F1 male mice showed a higher incidence of myocardial infarction than H-2^<d/b> F1 male mice. This observation suggests that the myocardial infarction seen in SLE may be related to MHC.
社団法人日本循環器学会の論文
1995-01-20