Long-Term Follow-up of the Circadian Rhythm of Heart Rate and Heart Rate Variability in Healthy Elderly Patients

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概要

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• Backgound The long-term age-related changes in circadian rhythm of heart rate variability (HRV), that is, autonomic nervous activity, remain unknown in elderly people. Methods and Results Holter monitoring was conducted twice at an interval of 15 years in 15 healthy elderly patients (age: 70.0±4.1 years, at first monitoring, female: 10) and assessed the age-related changes in 24-h mean and hourly mean normal sinus R-R interval (mean NN), HRV (high frequency (HF) component, low frequency (LF) component and LF/HF) and the circadian rhythms. As a result, 24-h mean mean NN (0.976±0.115 vs 0.903±0.117 (s), p=0.0019), LF/HF (1.681±0.731 vs 0.962±0.442, p=0.0022), and LF (278.88±176.43 vs 179.19±132.33 (ms^2), p=0.0039) significantly decreased 15 years later, although 24-h mean HF (221.20±138.89 vs 310.78±296.73 (ms^2), p=0.1102) increased slightly. The hourly mean NN closely correlated with hourly HF and LF/HF throughout circadian rhythms both at first and second monitoring. In the morning hours, amplitude rates of all HRV indices increased significantly 15 years later. Conclusion In elderly people, age-related changes in the 24-h mean heart rate (HR) were conversely dissociated from those of the 24-h mean HRV. However, the close correlation between hourly HR and HRV was preserved, even in very elderly patients. Additionally, the amplitude rates in HRV in the morning increased with age. These age-related changes of HR and HRV might be characteristic of elderly people.

• 社団法人日本循環器学会の論文
• 2006-06-20

著者

• SETO Shinji

  Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Bio

• Yano Katsusuke

  Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of B

• Yano Katsusuke

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano Katsusuke

  長崎大学 第3内科

• Seto Shinji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano Katsusuke

  Third Department Of Internal Medicine Nagasaki University School Of Medicine

• Yano Katsusuke

  Department Of Cardiology Nagasaki University Hospital

• Yano Katsusuke

  The Third Department Of Internal Medicine Nagasaki University School Of Medicine

• Tasaki Hirofumi

  Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Bio

• Serita Takumi

  Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Bio

• Ueyama Chiaki

  Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Bio

• Kitano Kouei

  Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Bio

• Seto Shinji

  Department Of Radiation Epidemiology Atomic Bomb Disease Institute

• Kitano Kouei

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Ueyama Chiaki

  Third Department Of Internal Medicine Nagasaki University School Of Medicine

• Ueyama Chiaki

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano Katsusuke

  Department Of Cardiovacular Medicine Nagasaki University

• Yano Katsusuke

  Faculty Of Health Management Nagasaki International University

• Tasaki Hirofumi

  Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biomedical Sciences

• Serita Takumi

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Seto Shinji

  The Third Department Of Internal Medicine Nagasaki University School Of Medicine

• Seto Shinji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Kitano Kouei

  The Third Department Of Internal Medicine Nagasaki University School Of Medicine

• Yano Katsusuke

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano Katsusuke

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano Katsusuke

  Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biomedical Sciences

• Seto Shinji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Yano K

  長崎大学 第3内科

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