Differences in Body Temperature Variability Between Subjects With and Without Diabetes and Predictive Value for Cardiovascular Events
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概要
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Background: Differences in regulating factors and the clinical implications of body temperature variability (BTV) between subjects with and without diabetes have not been clarified to date. Methods and Results: In 66 subjects with ischemic heart disease (33 with diabetes and 33 without diabetes), BTV, the difference between the highest and lowest temperature measurements, and body temperature standard deviation (BT SD) were measured from axillary body temperature (ABT) records of 3 consecutive days and followed for 16.4±8.4 months. In subjects without diabetes BTV and BT SD were closely associated with endothelial function as evaluated on flow-mediated dilation (BTV, R=0.33, P=0.026; BT SD, R=0.41, P=0.029), whereas there was a poor association in subjects with diabetes. In the absence of an interrelationship between vascular function and thermoregulation, the contribution of inflammation to BTV was increased in subjects with diabetes (BTV, 0.59±0.21°C for C-reactive protein [CRP] <0.08mg/dl vs. 0.79±0.28°C for CRP >0.08mg/dl, P=0.014). Event-free survival analysis showed that in subjects with diabetes higher BT SD was associated with shorter event-free survival (log-rank P=0.012), but this relationship was not found in subjects without diabetes. Conclusions: In subjects with diabetes, the interrelationship between thermoregulation and vascular function was disrupted and the effect of inflammation on thermoregulation was enhanced, so that BTV had a sufficient predictive value for cardiovascular events in diabetic subjects.
著者
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Nakao Tomoko
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Amiya Eisuke
Department Of Cardiovascular Medicine University Of Tokyo
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Hosoya Yumiko
Department Of Cardiology Sakakibara Heart Institute Japan Research Promotion Society For Cardiovascu
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Hirata Yasunobu
Department Of Advanced Clinical Science And Therapeutics Cardiovascular Medicine Graduate School Of
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Maemura Koji
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome
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Watanabe Masafumi
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Komuro Issei
Department Of Cardiovascular Medicine
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KAWARASAKI Shuichi
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
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Maemura Koji
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences
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Watanabe Aya
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University
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OZEKI Atsuko
Department of Cardiovascular Medicine, Graduate School of Medicine, the University of Tokyo
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Nagai Ryozo
Jichi Medical School
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Watanabe Shogo
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Takata Munenori
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Omori Kazuko
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Kawarasaki Shuichi
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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