Circadian Rhythms in the CNS and Peripheral Clock Disorders : Role of the Biological Clock in Cardiovascular Diseases

スポンサーリンク

概要

• 論文の詳細を見る

• The cardiovascular diseases are closely related to circadian rhythm, which is under the control of the biological clock. Clock genes show circadian oscillation not only in the suprachiasmatic nucleus but also in peripheral tissues, suggesting the existence of the peripheral clock. We previously demonstrated that plasminogen activator inhibitor-1 (PAI-1) might be an output gene of the peripheral clock. To further elucidate the functional relevance of the peripheral clock in the cardiovascular system, we screened target genes of the peripheral clock by cDNA microarray analysis. A total of 29 genes including transcription factor, growth factors, and membrane receptors were upregulated by CLOCK/BMAL and showed circadian oscillation. These results suggest that cardiovascular systems have their own peripheral clocks, and at least in part, they may regulate the circadian oscillation of cardiovascular function directly. These results potentially provide a molecular basis for the circadian variation of cardiovascular function and novel strategies for the prevention and treatment of cardiovascular diseases.

• 社団法人 日本薬理学会の論文
• 2007-02-20

著者

• NAGAI Ryozo

  Department of Cardiovascular Medicine, University of Tokyo

• Nagai Ryozo

  東京大学 心臓外科学

• Maemura Koji

  Department of Cardiovascular Medicine, The University of Tokyo

• Takeda Norihiko

  Department of Cardiovascular Medicine, University of Tokyo

• Nojiri Takefumi

  Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo

• Takeda Norihiko

  東京大学 循環器内科

• Takeda Norihiko

  東京大学 医学系研究科循環器内科学

• Takeda Norihiko

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Takeda Norihiko

  Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo

• Takeda Norihiko

  Department Of Applied Chemistry Faculty Of Engineering Osaka University

• Maemura Kouji

  Department Of Cardiovascular Medicine Nagasaki University

• Maemura Koji

  東京大学 循環器内科

• Maemura Koji

  東京大学 医学系研究科循環器内科学

• Maemura Koji

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Takeda Norifumi

  Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo

• Nakao Tomoko

  東京大学 循環器内科

• Maemura Koji

  Department Of Cardiovascular Medicine Nagasaki University

• Nishimura Takashi

  Department Of Therapeutic Strategy For End-stage Heart Failure The University Of Tokyo

• Maemura Kouji

  Graduate School Of Medicine And Faculty Of Medicine University Of Tokyo

• Maemura Koji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Nagai Ryozo

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Maemura Koji

  Department Of Ischemic Circulatory Physiology University Of Tokyo

• Maemura Koji

  Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine

• Tamura Noriko

  Department Of Cardiovascular Medicine Tokyo Medical And Dental University

• Takeda Norihiko

  Department Of Cardiovascular Medicine Tokyo Medical And Dental University

• Nagai Ryozo

  Department Of Cardiology Kitano Hospital Medical Research Institute

• Nagai Ryozo

  Department Cardiovascular Medicine The University Of Tokyo Hospital

関連論文

• Characteristics of Chronic Rejection in Heart Transplantation : Important Elements of Pathogenesis and Future Treatments
• Mid-Term Results and Costs of Coronary Artery Bypass vs Drug-Eluting Stents for Unprotected Left Main Coronary Artery Disease
• Effects of the AT_1 receptor blocker losartan and the calcium channel blocker benidipine on the accumulation of lipids in the kidney of a rat model of metabolic syndrome
• Role of Adiponectin in Preventing Vascular Stenosis : The Missing Link of Adipo-Vascular Axis
• SNP projects in Japan
• Production of Nitric Oxide, but Not Prostacyclin, Is Reduced in Klotho Mice
• Vascular Endothelial Growth Factor is an Autocrine Growth Factor for Cardiac Myxoma Cells
• Crosstalk between c-Src- and Smad-Dependent Pathways Regulates the TGF-β-Induced SMC-Specific Gene Expression in Murine Embryonic Fibroblast 10T1/2 Cells
• bFGF Inhibits the TGFβ-Induced SM22α Gene Expression by CBFA1 through MAP Kinase Pathways in Embryonic Fibroblast Cells
• Effects of Acute Hypoxia at Moderate Altitude on Stroke Volume and Cardiac Output During Exercise
• Intracoronary Serum Smooth Muscle Myosin Heavy Chain Levels Following PTCA may Predict Restenosis
• Beta-Blocker Prescription Among Japanese Cardiologists and Its Effect on Various Outcomes
• The Japanese National Health Screening and Intervention Program Aimed at Preventing Worsening of the Metabolic Syndrome
• A One-Year Study of the Antiatherosclerotic Effect of the Angiotensin-II Receptor Blocker Losartan in Hypertensive Patients : A Comparison With Angiotensin-Converting Enzyme Inhibitors
• Association between Cigarette Smoking, White Blood Cell Count, and Metabolic Syndrome as Defined by the Japanese Criteria
• A Case of Neonatal Lupus Erythematosus Presenting Delayed Dilated Cardiomyopathy With Circulating Autoantibody to Annexin A6
• Biochemical Diagnosis of Aortic Dissection: From Bench to Bedside
• An increase in superoxide production in klotho mice
• Activation of Heat-Shock Factor-1 by Statins in Endothelial Cells
• Induction of Heme Oxygenase 1 Gene Expression by Statin in Endothelial Cells
• Distinct effects of fibrate compounds and statins on the gene expression in bovine aortic endothelial cells
• Identification of the potent hypoxia-response element within the human PAI-1 promoter
• Cerivastatin inhibits the endothelin-1 gene transcription through heat shock response motif in vascular endothelial cells
• Effects of Nicorandil on Cardiovascular Events in Patients With Coronary Artery Disease in The Japanese Coronary Artery Disease (JCAD) Study
• Gender Differences in Patients With Coronary Artery Disease in Japan : The Japanese Coronary Artery Disease Study (The JCAD Study)
• Elevated Serum Uric Acid is an Independent Predictor for Cardiovascular Events in Patients With Severe Coronary Artery Stenosis : Subanalysis of the Japanese Coronary Artery Disease (JCAD) Study
• FRS-087 The Impact of Diabetes on the Prognosis of Japanese Patients with Coronary Artery Disease(FRS18,New Insights into Metabolic Syndrome (H),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Elevated Serum C-Reactive Protein Levels Predict Cardiovascular Events in the Japanese Coronary Artery Disease (JCAD) Study(Epidemiology)
• Demographics and Changes in Medical/Interventional Treatment of Coronary Artery Disease Patients Over a 3.5-Year Period in Japan : The Japanese Coronary Artery Disease Study: Trend Examination
• Rationale and Design of a Study to Examine Lower Targets for Low-Density Lipoprotein-Cholesterol and Blood Pressure in Coronary Artery Disease Patients : The Japanese Coronary Artery Disease Study II (JCADII)
• OJ-217 Genetic Variations of Mrf-2/Arid5B Confers Risk of Coronary Atherosclerosis in the Japanese Population(Genetics/Genetically engineered models/Gene therapy-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Adipose Tissue Remodeling and Malfunctioning in Obesity Revealed by in vivo Molecular Imaging
• PJ-482 The Polymorphism in the Adiponectin Gene is Associated with Susceptibility to Coronary Artery Disease(Atherosclerosis, clinical-11 (H) PJ81,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society
• PE-145 The Clinical Application of the Pharmacogenomics for Optimizing Warfarin Dosage(PE025,Thromboembolism/Antithrombotic Therapy/Thrombolysis 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Evidence for association of Ser326Cys polymorphism in 8-oxyguanin DNA glycosylase (OGG1) with susceptibility to coronary heart disease in Japanese
• Cultured Vascular Endothelial Cells Show Circadian Oscillation of Clock Related Genes
• Angiotensin II stimulation induces TGF β and its related proteins in cardiac fibroblasts
• Establishment of clinical data management system and its practical application to genetic epidemiology in cardiovascular medicine
• A New Therapeutic Strategy for Hypertrophic Nonobstructive Cardiomyopathy in Humans : A Randomized and Prospective Study With an Angiotensin II Receptor Blocker
• Morbidity Prevalence Rate of Kawasaki Disease Assessed by Single Cross-Sectional History-Taking
• Focalized Contractile Impairment at Hypertrophied Myocardium Proven in Consideration of Wall Stress in Patients With Hypertrophic Cardiomyopathy
• Development of a Pioneering Clinical Support System Utilizing Information Technology : Clinical Informatics and Genome Analysis
• Successful Catheter Intervention for Acute Coronary Syndrome in a Patient with Antiphospholipid Syndrome
• Genetic Variations of Mrf-2/Arid5b Confer Risk of Coronary Atherosclerosis in the Japanese Population
• PE-566 Variations in the Origins of Mature Smooth Muscle Cells with SM1/2 Expression in Vascular Remodeling(Development and differentiation-3 (M) PE97,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soci
• Genetic Analysis in a Patient With Recurrent Cardiac Myxoma and Endocrinopathy
• PE-301 Kruppel-like Factor 6 is a Key Transcription Factor in Adipocyte Differentiation(PE051,Metabolic Syndrome 3 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-260 Positive Regulation of Promoter-Region Specific Histone Incorporation by Histone Chaperones ANP32B and TAF-I, Histone Deacetylase HDAC1 and DNA-Binding Factor KLF5(PE044,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meet
• DPE-072 A Novel Pathogenic Pathway of DNA Damage Response as Mediated by KLF5 and Its Transcriptional Complexes in the Cardiovasculature(DPE12,Cardiomyopathy/Hypertrophy (Basic) (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of Th
• OE-258 Kruppel-like Factor 6 is a Key Transcription Factor That Controls Cardiac Fibrosis(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-173 A novel pathogenic pathway of DNA damage response as mediated by KLF5 and its transcriptional complexes in the cardiovasculature(Molecular biology, vascular(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circ
• OJ-259 Acyclic Retinoid Inhibits Neointima Formation through Retinoic Acid Receptor Beta-induced Apoptosis(Cardiovascular pharmacology, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-173 A Novel Regulatory Pathway of DNA Damage Response to Pathologic Vascular Injury as Mediated by KLF5 and its Transcriptional Complexes(Molecular biology, vascular-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-048 Angiotensin II Activates the DNA Damage Response through Nitric Oxide in Vascular Endothelial Cells(Cardiac hypertrophy, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-008 Cellular Proteomic Approach to Identify Transforming Growth Factor (TGF)-beta Induced DNA and/or RNA-binding Factors(Molecular biology, vascular-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-299 Acyclic Retinoid is a Possible Oral Therapeutic Agent against Neointimal Hyperplasia(Cardiovascular pharmacology, basic/clinical-1 (H) OE50,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
• Acyclic Retinoid Prevents Cardiovascular Remodeling by Regulated KLF5(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• The Cardiovascular Transcription Factor Kruppel-like Factor 5 is Negatively Regulated by the Deacetylase HDAC1 through Direct Interaction(Molecular Biology, Vascular 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Proteomic Identification of a Novel Regulatory Pathway of Pathologic Induction of PDGF-A as Mediated by KLF5 with Transcriptional Cofactors(Molecular Biology, Vascular 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-399 Anti-apoptotic effects of the cardiovascular transcription factor KLF5(Apoptosis/Necrosis/Regeneration 2 (M) : PE68)(Poster Session (English))
• Beta-Blocker Prescription Among Japanese Cardiologists and Its Effect on Various Outcomes
• Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients
• FRS-060 SUMOylation of KLF5 is a key molecular switch of transcriptional regulatory programs of lipid metabolism(New Insights into Metabolic Syndrome(02)(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-537 Identification of the Novel MEF2-Kruppel-like Factor 5 (KLF5) Network That Associates with Cardiovascular Disease(Molecular biology, vascular-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-411 KLF5 Controls Metabolic Stress Response in Metabolic Syndrome and Cardiovascular Disease(Diabetes/Obesity/Metabolic syndrome-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-174 Molecular Mechanism of Soluble Form of VEGFR-1 (sVEGFR-1)Expression in Vascular Endothelial Cell(Molecular biology, vascular(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-044 Long Pentraxin 3 (PTX3) is More Specific than C-reactive Protein (CRP) as a Marker for Vascular Inflammation(Atherosclerosis, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-019 Peripheral Clock Regulates Circadian Thrombomodulin Gene Expression in Vascular Endothelial Cells(Molecular biology, vascular-1 (H) OE4,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Resistin Induces Adhesion Molecules through NF-κB Pathway in Vascular Endothelial Cells(Infection/Inflammation/Immunity 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Resistin Inhibits Endothelial Cell Migration and Angiogenesis(Metabolic Syndrome (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-447 The genetic polymorphisms in the insulin-resistance related genes as coronary risks(Preventive Medicine/Epidemiology/Education 4 (H) : PJ75)(Poster Session (Japanese))
• OJ-171 CRP Induces PAI-1 Gene Expression through Tyrosine Kinase and NF-κB Signaling Pathways(Infection/Inflammation/Immunity 1 (H) : OJ20)(Oral Presentation (Japanese))
• Carvedilol Therapy Improved Left Ventricular Function in a Patient With Arrhythmogenic Right Ventricular Cardiomyopathy
• Lack of Insulin Receptor Substrate-2 Is a Link between Insulin Resistance and an Increased Intima of the Vessel in Mice
• Three-vessel Coronary Artery Disease Complicated with Congestive Heart Failure in a Highly Aged Patient with Tetralogy of Fallot Having Undergone Palliative Surgeries
• OJ-022 Molecular and Physiological Characteristics of Transient Voltage-dependent K^+ Currents (Kv) in Human Pulmonary Arterial Smooth Muscle Cells(Excitation-Contraction Coupling/Ion Channel (A) : OJ3)(Oral Presentation (Japanese))
• Medical Examination at University Entrance Should Include Intensive History-Taking for Kawasaki Disease to Prevent Cardiac Sudden Death in Campus Life
• Prevalence of Vitreous Hemorrhage Following Coronary Revascularization in Patients With Diabetic Retinopathy
• A Novel Technique to Measure Ca^ Concentration in Sarcoplasmic Reticulum of Cardiomyocytes
• Characteristic Effects of α1-β_1,2-Adrenergic Blocking Agent, Carvedilol, on [Ca^2+]_i in Ventricular Myocytes Compared With Those of Timolol and Atenolol
• Upregulated Neurohumoral Factors are Associated With Left Ventricular Remodeling and Poor Prognosis in Rats With Monocrotaline-Induced Pulmonary Arterial Hypertension
• Signaling Pathways Responsible for Fetal Gene Expression in the Failing Human Heart- Evidence for Altered Thyroid Hormone Receptor Gene Expression
• Dominant Negative Mutants of Transcriptional Factor AP-1 Dissociates Cardiac Myocyte Hypertrophy and Pathologic Gene Program
• Inhibition of Histone Deacetylase Reverses Repression of Myocyte-Specific Gene Expression Associated with Cardiac Hypertrophy
• Endothelin-1 facilitates inotropism via Rho kinase-dependent myosin light chain kinase activation in adult rat ventricular myocytes
• Both plasma atrial natriuretic peptide and immediate improvement of left ventricular stroke volume as useful predictors of outcome of cardioversion
• Half disruption of Na/Ca exchanger Gene Increases the [Ca^] Amplitude due to Sarcoplasmic Reticulum Ca^ Overload in Murine Ventricular Myocytes
• Hypertrophic Cardiomyopathy With Midventricular Obstruction and Apical Aneurysm : A Case Report
• Left Ventricular Relaxation Abnormality Is Detectable by Analysis of the Relaxation Time Constant in Patients With Atrial Fibrillation
• Anthracycline-Induced Cardiomyopathies Evaluated by Tissue Doppler Tracking System and Strain Rate Imaging
• IS005 Cell Swelling-induced Increase in Delayed-rectifier K Current is Mediated by Autocrine Release of ATP
• Kruppel-Like Zinc-Finger Transcription Factor KLF5/BTEB2 ls a Target for Angiotensin II Signaling and an Essential Regulator of Cardiovascular Remodeling.
• Retroperitoneal Fibrosis With Periaortic and Pericardial Involvement
• Obese adipose tissue remodeling, malfunctioning, and chronic inflammation visualized by in vivo molecular imaging
• PJ-178 Free Fatty Acid, Palmitate, Induces Metabolic and Vascular Lipotoxicity via the IRE1 Arm of ER Stress Response Pathways(PJ030,Metabolic Syndrome 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-165 Psychosocial Status of Patients with Left Ventricular Assist Device and Their Needs during Therapy in Japan(PJ028,Cardiovascular Pharmacology (Basic), Cost-health care system/DPC/Laws (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting
• PE-513 Three Dimensional Echocardiography Provides New Indexes for the Evaluation of Pulmonary Hypertension(PE086,Pulmonary Circulation (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
• PE-505 Resistance Training Combined with Aerobic One Effectively Improves Exercise Capacity in Patients Implanted with TOYOBO LVAS(PE085,Exercise Test/Cardiac Rehabilitation (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese C
• PE-244 Less Frequency of Native Aortic Valve Opening Causes Aortic Regurgitation in Patients with Left Ventricular Assist Device (LVAD)(PE041,Transplantation/LVAD (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
• PE-241 Preoperative Clinical Profiles Predict Prognosis after Left Ventricular Assist Device Implantation(PE041,Transplantation/LVAD (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

もっと見る 閉じる

スポンサーリンク