Circadian Rhythms in the CNS and Peripheral Clock Disorders : Role of the Biological Clock in Cardiovascular Diseases
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概要
- 論文の詳細を見る
The cardiovascular diseases are closely related to circadian rhythm, which is under the control of the biological clock. Clock genes show circadian oscillation not only in the suprachiasmatic nucleus but also in peripheral tissues, suggesting the existence of the peripheral clock. We previously demonstrated that plasminogen activator inhibitor-1 (PAI-1) might be an output gene of the peripheral clock. To further elucidate the functional relevance of the peripheral clock in the cardiovascular system, we screened target genes of the peripheral clock by cDNA microarray analysis. A total of 29 genes including transcription factor, growth factors, and membrane receptors were upregulated by CLOCK/BMAL and showed circadian oscillation. These results suggest that cardiovascular systems have their own peripheral clocks, and at least in part, they may regulate the circadian oscillation of cardiovascular function directly. These results potentially provide a molecular basis for the circadian variation of cardiovascular function and novel strategies for the prevention and treatment of cardiovascular diseases.
- 社団法人 日本薬理学会の論文
- 2007-02-20
著者
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NAGAI Ryozo
Department of Cardiovascular Medicine, University of Tokyo
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Nagai Ryozo
東京大学 心臓外科学
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Maemura Koji
Department of Cardiovascular Medicine, The University of Tokyo
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Takeda Norihiko
Department of Cardiovascular Medicine, University of Tokyo
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Nojiri Takefumi
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Takeda Norihiko
東京大学 循環器内科
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Takeda Norihiko
東京大学 医学系研究科循環器内科学
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Takeda Norihiko
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Takeda Norihiko
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Takeda Norihiko
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Maemura Kouji
Department Of Cardiovascular Medicine Nagasaki University
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Maemura Koji
東京大学 循環器内科
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Maemura Koji
東京大学 医学系研究科循環器内科学
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Maemura Koji
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Takeda Norifumi
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Nakao Tomoko
東京大学 循環器内科
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Maemura Koji
Department Of Cardiovascular Medicine Nagasaki University
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Nishimura Takashi
Department Of Therapeutic Strategy For End-stage Heart Failure The University Of Tokyo
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Maemura Kouji
Graduate School Of Medicine And Faculty Of Medicine University Of Tokyo
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Maemura Koji
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome
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Nagai Ryozo
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Maemura Koji
Department Of Ischemic Circulatory Physiology University Of Tokyo
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Maemura Koji
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Tamura Noriko
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
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Takeda Norihiko
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
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Nagai Ryozo
Department Of Cardiology Kitano Hospital Medical Research Institute
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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